Linked Life Data

10090710

Source:http://linkedlifedata.com/resource/pubmed/id/10090710

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1999-6-21
pubmed:abstractText
We found an epidemic of juvenile hypothyroidism among a population of self-defined "downwinders" living near the Hanford nuclear facility located in southeast Washington State. The episode followed massive releases of 131I. Self-reported data on 60 cases of juvenile hypothyroidism (<20 years of age) among a group of 801 Hanford downwinders are presented, as well as data concerning the thyroid status of approximately 160,000 children exposed to radioiodine before 10 years of age as a result of the 26 April 1986 Chernobyl explosion in the former Soviet Union. These children were residents of five regions near Chernobyl. They were examined by standardized screening protocols over a period of 5 years from 1991 to 1996. They are a well-defined group of 10 samples. Fifty-six cases of hypothyroidism were found among boys and 92 among girls. Body burdens of 137Cs have been correlated with hypothyroidism prevalence rates. On the other hand, the group of juvenile (<20 years of age) Hanford downwinders is not a representative sample. Most of the 77 cases of juvenile hypothyroidism in the Hanford group were diagnosed from 1945 to 1970. However, the ratio of reported cases to the county population under 20 years of age is roughly correlated with officially estimated mean levels of cumulative thyroid 131I uptake in these counties, providing evidence that juvenile hypothyroidism was associated with radioiodine exposures. Because even subtle hypothyroidism may be of clinical significance in childhood and can be treated, it may be useful to screen for the condition in populations exposed to radioiodine fallout. Although radiation exposure is associated with hypothyroidism, its excess among fallout-exposed children has not been previously quantified.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0091-6765
pubmed:author
pubmed:issnType
Print
pubmed:volume
107
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
303-8
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:10090710-Adolescent, pubmed-meshheading:10090710-Adult, pubmed-meshheading:10090710-Body Burden, pubmed-meshheading:10090710-Cesium Radioisotopes, pubmed-meshheading:10090710-Child, pubmed-meshheading:10090710-Child, Preschool, pubmed-meshheading:10090710-Cohort Effect, pubmed-meshheading:10090710-Disasters, pubmed-meshheading:10090710-Disease Outbreaks, pubmed-meshheading:10090710-Environmental Exposure, pubmed-meshheading:10090710-Female, pubmed-meshheading:10090710-Follow-Up Studies, pubmed-meshheading:10090710-Humans, pubmed-meshheading:10090710-Hypothyroidism, pubmed-meshheading:10090710-Incidence, pubmed-meshheading:10090710-Infant, pubmed-meshheading:10090710-Iodine Radioisotopes, pubmed-meshheading:10090710-Male, pubmed-meshheading:10090710-Power Plants, pubmed-meshheading:10090710-Radioactive Hazard Release, pubmed-meshheading:10090710-Radioactive Pollutants, pubmed-meshheading:10090710-Retrospective Studies, pubmed-meshheading:10090710-Space-Time Clustering, pubmed-meshheading:10090710-Ukraine, pubmed-meshheading:10090710-Washington
pubmed:year
1999
pubmed:articleTitle
Juvenile hypothyroidism among two populations exposed to radioiodine.
pubmed:affiliation
Department of Epidemiology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheeva, Israel.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't