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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1999-5-25
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pubmed:abstractText |
We wished to determine if the effects of injected recombinant human leukemia inhibitory factor (LIF) are a function of endogenous goat interleukin-1 (IL-1) production and, conversely, if the effects of injected recombinant human IL-1 are a function of endogenous LIF production in goat radiocarpal joints (RCJ). In preliminary experiments, murine LIF binding protein (MuLBP) and recombinant HuIL-1RA were found to independently attenuate the cartilage proteoglycan resorbing activity of goat synovial membrane-conditioned medium (GSMCM), implying activity against goat LIF and goat IL-1, respectively. The present study shows that the proinflammatory and chondral actions of rHuLIF in goat RCJ are partially attenuated by rHuIL-1RA. This implies that a small but important component of the in vivo activity of rHuLIF is a result of IL-1 production in the synovial joint. With the exception of proteoglycan synthesis, the absence of significant effects by MuLBP on the actions of rHuIL-1alpha in goat RCJ suggests that the proinflammatory and chondral effects of IL-1alpha in vivo are probably not mediated by LIF.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media, Conditioned,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/LIF protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/LIFR protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Leukemia Inhibitory Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Leukemia Inhibitory Factor...,
http://linkedlifedata.com/resource/pubmed/chemical/Lif protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Lifr protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphokines,
http://linkedlifedata.com/resource/pubmed/chemical/Proteoglycans,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytokine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, OSM-LIF,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1079-9907
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
197-208
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10090405-Animals,
pubmed-meshheading:10090405-Cartilage, Articular,
pubmed-meshheading:10090405-Culture Media, Conditioned,
pubmed-meshheading:10090405-Growth Inhibitors,
pubmed-meshheading:10090405-Humans,
pubmed-meshheading:10090405-Inflammation,
pubmed-meshheading:10090405-Interleukin-1,
pubmed-meshheading:10090405-Interleukin-6,
pubmed-meshheading:10090405-Leukemia Inhibitory Factor,
pubmed-meshheading:10090405-Leukemia Inhibitory Factor Receptor alpha Subunit,
pubmed-meshheading:10090405-Lymphokines,
pubmed-meshheading:10090405-Mice,
pubmed-meshheading:10090405-Proteoglycans,
pubmed-meshheading:10090405-Receptors, Cytokine,
pubmed-meshheading:10090405-Receptors, OSM-LIF,
pubmed-meshheading:10090405-Recombinant Proteins,
pubmed-meshheading:10090405-Stimulation, Chemical,
pubmed-meshheading:10090405-Synovial Membrane
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pubmed:year |
1999
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pubmed:articleTitle |
The proinflammatory and chondral activities of leukemia inhibitory factor in goat joints are partially a function of interleukin-1.
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pubmed:affiliation |
Department of Rheumatology and the Research Centre, Royal Perth Hospital, Western Australia, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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