This study was undertaken to identify gene(s) that may be associated with improved clinical outcome in patients with congestive heart failure (CHF). The adenosine monophosphate deaminase locus (AMPD1) was selected for study. We hypothesized that inheritance of the mutant AMPD1 allele is associated with increased probability of survival without cardiac transplantation in patients with CHF.
Cardiovascular Division, Department of Medicine, Biostatistics and Epidemiology, Hospital of the University of Pennsylvania, University of Pennsylvania, Philadelphia, PA 19104, USA. lohe@mail.med.upenn.edu