Linked Life Data

10084779

Source:http://linkedlifedata.com/resource/pubmed/id/10084779

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1999-4-13
pubmed:abstractText
Glucocorticoids in pharmacological doses interfere with the integrity of the somatotropics hormone axis. However, the apparent discrepancies between the in vitro and in vivo studies, short-term vs. long-term exposure, and species-specific changes complicate a clear assessment of these interactions. The growth-depressing effects of glucocorticoids are multifactorial and involve suppression of pituitary GH release by stimulating hypothalamic somatostatin tone, down-regulation of hepatic GH receptors, inhibition of GH bioactivity by the induction of IGF inhibitors, complex alteration of the IGFBP serum profile, and a direct suppressive effect on tissue matrix production and synthesis of local growth factors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1397-3142
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
183-9
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
Interactions between glucocorticoids and the growth hormone-insulin-like growth factor axis.
pubmed:affiliation
Division of Pediatric Nephrology, Heidelberg University Children's Hospital, Germany. Burkhard_Toenshoff@krzmail.krz.uni-heidelberg.de
pubmed:publicationType
Journal Article, Review