Source:http://linkedlifedata.com/resource/pubmed/id/10079267
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
1999-4-13
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| pubmed:abstractText |
Nephron reduction is an important factor in the development of glomerulosclerosis. In a study of the oligosyndactyly (Os) mutation that causes a congenital 50% reduction in nephron number, we previously found that ROP Os/+ mice developed glomerulosclerosis whereas C57B1/6J Os/+ mice did not. We concluded that the predisposition to glomerulosclerosis depended largely on the genetic background, the ROP being sclerosis-prone whereas the C57 strain was sclerosis-resistant. In the current experiments we asked whether the intensity of the sclerotic response to nephron reduction in the ROP strain was related to the time at which it occurred, ie, a pre- or post-natal event. We also determined whether the absence of lesions in C57 Os/+ mice was caused by a higher threshold for the induction of a sclerotic response in C57 mice. We further examined the relationship between glomerular hypertrophy and sclerosis. C57 +/+, C57 Os/+, ROP +/+, and ROP Os/+ mice were uninephrectomized (NX) at age 10 weeks and followed for 8 weeks. We found no sclerotic changes in NX C57 +/+ and C57 Os/+ mice, despite a 75% reduction in nephron number in the latter. In contrast, both NX ROP +/+ and NX ROP Os/+ mice had glomerulosclerosis, which was more severe in the NX ROP Os/+ mice. Examination of extracellular matrix synthesis and degradation at the mRNA level revealed that synthesis exceeded degradation in ROP Os/+ mice. The lesions in NX ROP +/+ were less severe than in sham-operated ROP/Os mice, suggesting that the timing of nephron reduction affected the amplitude of the sclerotic response in this strain. Following NX, an increase in glomerular volume was found in C57 +/+, ROP +/+, and ROP Os/+ mice. However, NX did not lead to a further increase in glomerular volume in C57 Os/+ mice. We make three conclusions: 1) sclerosis was more severe in the ROP strain when nephron reduction occurred in utero; 2) the absence of glomerulosclerosis in C57 mice was not related to a higher threshold for a sclerosis response in this strain; and 3) whereas glomerular size continued to increase as nephron number decreased in ROP mice, it reached a plateau in C57 mice.
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| pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10079267-1443183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10079267-1583888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10079267-1732588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10079267-1753707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10079267-2308261,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/10079267-8510390,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/10079267-8636436,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/10079267-9853264
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
0002-9440
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
154
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
891-7
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| pubmed:dateRevised |
2009-11-18
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| pubmed:meshHeading |
pubmed-meshheading:10079267-Animals,
pubmed-meshheading:10079267-Body Weight,
pubmed-meshheading:10079267-Female,
pubmed-meshheading:10079267-Glomerulosclerosis, Focal Segmental,
pubmed-meshheading:10079267-Kidney Glomerulus,
pubmed-meshheading:10079267-Mice,
pubmed-meshheading:10079267-Mice, Inbred C57BL,
pubmed-meshheading:10079267-Mice, Mutant Strains,
pubmed-meshheading:10079267-Nephrectomy,
pubmed-meshheading:10079267-Organ Size,
pubmed-meshheading:10079267-Postoperative Period,
pubmed-meshheading:10079267-RNA, Messenger,
pubmed-meshheading:10079267-Species Specificity,
pubmed-meshheading:10079267-Time Factors
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| pubmed:year |
1999
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| pubmed:articleTitle |
Nature and severity of the glomerular response to nephron reduction is strain-dependent in mice.
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| pubmed:affiliation |
Division of Nephrology, IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
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| pubmed:publicationType |
Journal Article
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