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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1999-4-13
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pubmed:databankReference |
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pubmed:abstractText |
BCG-CWS is a therapeutically potent immune activator which improves the prognosis of cancer patients. However, the targeting effector cells and molecules for BCG-CWS in the human immune system have not been determined. Here, we found that BCG-CWS activates human monocytes and concomitantly down-regulates expression of a human homologue of chicken MD-1 in the activated monocytes by differential display. According to a previous study, MD-1 forms a complex with the Toll family protein RP-105 on murine B cell lines to facilitate its stable expression. Thus, MD-1 may participate in regulation of innate immune activation on human monocytes. Our results, taken together with these recent findings regarding Toll family proteins, suggest that BCG-CWS acts on monocytes to modulate the human innate immune system via regulation of Toll family proteins.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 1999 Academic Press.
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
256
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
325-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10079183-Amino Acid Sequence,
pubmed-meshheading:10079183-Animals,
pubmed-meshheading:10079183-Antigens, CD,
pubmed-meshheading:10079183-Antigens, Surface,
pubmed-meshheading:10079183-Base Sequence,
pubmed-meshheading:10079183-Cell Separation,
pubmed-meshheading:10079183-Cell Size,
pubmed-meshheading:10079183-Cell Wall Skeleton,
pubmed-meshheading:10079183-Cells, Cultured,
pubmed-meshheading:10079183-Cloning, Molecular,
pubmed-meshheading:10079183-DNA Primers,
pubmed-meshheading:10079183-Dose-Response Relationship, Drug,
pubmed-meshheading:10079183-Down-Regulation,
pubmed-meshheading:10079183-Humans,
pubmed-meshheading:10079183-Molecular Sequence Data,
pubmed-meshheading:10079183-Monocytes,
pubmed-meshheading:10079183-Mycobacterium bovis,
pubmed-meshheading:10079183-Polymerase Chain Reaction,
pubmed-meshheading:10079183-RNA, Messenger,
pubmed-meshheading:10079183-Sequence Homology, Nucleic Acid,
pubmed-meshheading:10079183-Tumor Cells, Cultured
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pubmed:year |
1999
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pubmed:articleTitle |
Human MD-1 homologue is a BCG-regulated gene product in monocytes: its identification by differential display.
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pubmed:affiliation |
Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari-ku, Osaka, 537.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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