Source:http://linkedlifedata.com/resource/pubmed/id/10075745
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1999-4-7
|
| pubmed:abstractText |
The roots of T. x media Rehd. cv. Hicksii gave three novel analogues of paclitaxel modified at the N-acyl residue (N-debenzoyl-N-alpha-methylbutyryl paclitaxel and N-debenzoyl-N-cinnamoyl paclitaxel, 1b and 1c, respectively) or at the ester group at C-2 (2-debenzoyl-2-tigloyl paclitaxel, 1d). Compounds 1b and 1d showed reduced cytotoxicity and tubulin binding compared to paclitaxel, while 1c retained substantial activity in these assays.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0163-3864
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
62
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
219-23
|
| pubmed:dateRevised |
2000-12-18
|
| pubmed:meshHeading |
pubmed-meshheading:10075745-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:10075745-Chromatography, Liquid,
pubmed-meshheading:10075745-Drug Screening Assays, Antitumor,
pubmed-meshheading:10075745-Paclitaxel,
pubmed-meshheading:10075745-Plant Roots,
pubmed-meshheading:10075745-Spectrum Analysis,
pubmed-meshheading:10075745-Structure-Activity Relationship,
pubmed-meshheading:10075745-Trees
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Paclitaxel analogues from Taxus x media cv. Hicksii.
|
| pubmed:affiliation |
Indena S.p.A, via Don Minzoni 6, 20090 Settala (MI), Dipartimento di Scienza e Tecnologia del Farmaco, via Giuria 9, 10125 Torino, Italy. speclab@tin.it
|
| pubmed:publicationType |
Journal Article
|