Linked Life Data

10075162

Source:http://linkedlifedata.com/resource/pubmed/id/10075162

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1999-5-10
pubmed:abstractText
Atherosclerosis is the predominant underlying pathology responsible for coronary heart disease (CHD). It bears all the hallmarks of a chronic inflammatory disease and typical atherosclerotic lesions contain activated macrophages and T-cells. There have been several reports of possible associations between prior exposure to a number of specific micro-organisms and subsequent CHD, and prospective epidemiological studies have reported that elevated plasma levels of particular acute phase reactants (APRs) are predictors of future cardiac events. Investigators have also shown that immunisations exacerbate atherosclerosis in experimental animal models. These data raise the possibility that immunostimulation associated with natural infection by certain organisms, or vaccination, may promote atherosclerosis. A hypothesis which may explain all these findings, is that the cellular--and perhaps humoral--responses associated with immune stimulation may enhance atherogenesis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0264-410X
pubmed:author
pubmed:issnType
Print
pubmed:day
12
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
559-64
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Infection, immunisation and atherosclerosis: is there a link?
pubmed:affiliation
Centre for Clinical Science and Measurement, School of Biological Sciences, University of Surrey, Guildford, United Kingdom.
pubmed:publicationType
Journal Article, Review