Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1999-4-19
pubmed:abstractText
The results of PCR-based molecular typing of Helicobacter pylori strains by restriction fragment length polymorphism analysis of a 1, 161-bp nucleotide sequence of the midregion of the vacA gene are reported. A total of 48 H. pylori strains isolated from gastric biopsy specimens obtained from 18 patients with peptic ulcer dyspepsia, 15 patients with nonulcer dyspepsia, and 15 asymptomatic H. pylori-infected subjects were studied. Highly heterogeneous restriction patterns were obtained by digestion of PCR products with SauII, BglII, and HhaI, whereas HaeIII digestion resulted in a strictly homogeneous profile for H. pylori strains isolated from 14 of 18 (77.7%) patients with peptic ulcer dyspepsia, but a strictly homogeneous profile was found for strains from only 8 of 15 (53.3%) patients with nonulcer dyspepsia (P = 0.163) and 5 of 15 (33.3%) asymptomatic H. pylori-infected subjects (P = 0.014). A potentially important aspect of the results obtained is the clinical relevance, since a single restriction pattern seems to be able to identify the majority of H. pylori strains associated with peptic ulcer disease.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10074500-1313051, http://linkedlifedata.com/resource/pubmed/commentcorrection/10074500-1361982, http://linkedlifedata.com/resource/pubmed/commentcorrection/10074500-1401190, http://linkedlifedata.com/resource/pubmed/commentcorrection/10074500-1587837, http://linkedlifedata.com/resource/pubmed/commentcorrection/10074500-2307514, http://linkedlifedata.com/resource/pubmed/commentcorrection/10074500-3385767, http://linkedlifedata.com/resource/pubmed/commentcorrection/10074500-388439, http://linkedlifedata.com/resource/pubmed/commentcorrection/10074500-5432063, http://linkedlifedata.com/resource/pubmed/commentcorrection/10074500-7629077, http://linkedlifedata.com/resource/pubmed/commentcorrection/10074500-7639231, http://linkedlifedata.com/resource/pubmed/commentcorrection/10074500-7806390, http://linkedlifedata.com/resource/pubmed/commentcorrection/10074500-7908671, http://linkedlifedata.com/resource/pubmed/commentcorrection/10074500-8040281, http://linkedlifedata.com/resource/pubmed/commentcorrection/10074500-8099088, http://linkedlifedata.com/resource/pubmed/commentcorrection/10074500-8144644, http://linkedlifedata.com/resource/pubmed/commentcorrection/10074500-8163943, http://linkedlifedata.com/resource/pubmed/commentcorrection/10074500-8168917, http://linkedlifedata.com/resource/pubmed/commentcorrection/10074500-8478069, http://linkedlifedata.com/resource/pubmed/commentcorrection/10074500-8516329, http://linkedlifedata.com/resource/pubmed/commentcorrection/10074500-8730262, http://linkedlifedata.com/resource/pubmed/commentcorrection/10074500-8733223, http://linkedlifedata.com/resource/pubmed/commentcorrection/10074500-8937937, http://linkedlifedata.com/resource/pubmed/commentcorrection/10074500-8978347, http://linkedlifedata.com/resource/pubmed/commentcorrection/10074500-9196179, http://linkedlifedata.com/resource/pubmed/commentcorrection/10074500-9220168, http://linkedlifedata.com/resource/pubmed/commentcorrection/10074500-9542913, http://linkedlifedata.com/resource/pubmed/commentcorrection/10074500-9574690, http://linkedlifedata.com/resource/pubmed/commentcorrection/10074500-9574692
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0095-1137
pubmed:author
pubmed:issnType
Print
pubmed:volume
37
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
912-5
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
PCR-based restriction pattern typing of the vacA gene provides evidence for a homogeneous group among Helicobacter pylori strains associated with peptic ulcer disease.
pubmed:affiliation
Sezione di Microbiologia DMCSS, Policlinico S. Orsola, University of Bologna, Bologna, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't