Linked Life Data

10074252

Source:http://linkedlifedata.com/resource/pubmed/id/10074252

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1999-4-14
pubmed:abstractText
Effects of cellular hypoxia on [Ca2+]i in CK1.4 cells expressed Na(+)-Ca2+ exchange protein were determined by fura-2 fluorescence imaging. In vitro perfused of canine cardiovascular samples (37 degrees C), changes of aortic, cervical, pulmonary arterial smooth myogenic tone and cardiac papillary myogenic tone were measured by mechanic-electrical transducers via a computer-aid autosampling system. In the whole dogs, pharmacolkinetic parameters of a VISA agent at three dosages were calculated by 125Isod-1 scintillation counting according to a 6 x 6 statistical model. The results indicated that 1. hypoxia inhibited the Na(+)-Ca2+ exchange protein induced by and elevated Ca(2+)-influx and [Ca2+]i in the CK1.4 cells; 2. hypoxic perfusions depressed the AlF4-(-)activated myogenic vasoconstriction in aortic, cervical and pulmonary arteries, but facilitated the cardiac papillary myogenic contraction Ca(2+)-influx-induced, the finding was consistent with the first result; and 3. the VISA agent distributed in the cell together with AlF4- simulated and activated G-protein-sensitive transmembrane sygnal, and signhificantly improved the oxidative injuries of the transmembrane macrowolecules and cardiovascular contraction proteins such as Na(+)-Ca2+ exchange protein induced by hypoxia.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1000-6834
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
181-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
[Regulation of cardiovascular myogenic tone via G-protein-sensitive transmembrane signal pathways].
pubmed:affiliation
Department of Anesthesiology, Shanghai Medical University.
pubmed:publicationType
Journal Article, English Abstract, Research Support, Non-U.S. Gov't