| pubmed-article:10069377 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10069377 | lifeskim:mentions | umls-concept:C0019682 | lld:lifeskim |
| pubmed-article:10069377 | lifeskim:mentions | umls-concept:C0019699 | lld:lifeskim |
| pubmed-article:10069377 | lifeskim:mentions | umls-concept:C0035668 | lld:lifeskim |
| pubmed-article:10069377 | lifeskim:mentions | umls-concept:C0040624 | lld:lifeskim |
| pubmed-article:10069377 | lifeskim:mentions | umls-concept:C1145667 | lld:lifeskim |
| pubmed-article:10069377 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:10069377 | lifeskim:mentions | umls-concept:C0013879 | lld:lifeskim |
| pubmed-article:10069377 | lifeskim:mentions | umls-concept:C0301869 | lld:lifeskim |
| pubmed-article:10069377 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10069377 | pubmed:dateCreated | 1999-4-13 | lld:pubmed |
| pubmed-article:10069377 | pubmed:abstractText | HIV gene expression is crucially dependent on binding of the viral Tat protein to the transactivation RNA response element. A number of synthetic Tat-transactivation responsive element interaction inhibitors of peptide/peptoid nature were described as potential antiviral drug prototypes. We present a new class of peptidomimetic inhibitors, conjugates of L-arginine with aminoglycosides. Using a gel-shift assay and affinity chromatography on an L-arginine column we found that these compounds bind specifically to the transactivation responsive element RNA in vitro with Kd values in the range of 20-400 nM, which is comparable to the Kd of native Tat bound to the transactivation responsive element (10-12 nM). Confocal microscopy studies demonstrated that fluorescein-labelled conjugate penetrates into live cells. High affinity to the transactivation responsive element, low toxicity, and relative simplicity of synthesis make these compounds attractive candidates for antiviral drug design. | lld:pubmed |
| pubmed-article:10069377 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10069377 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10069377 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10069377 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10069377 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10069377 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10069377 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10069377 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10069377 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10069377 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10069377 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10069377 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10069377 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:10069377 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:10069377 | pubmed:author | pubmed-author:LapidotAA | lld:pubmed |
| pubmed-article:10069377 | pubmed:author | pubmed-author:EvdokimovA... | lld:pubmed |
| pubmed-article:10069377 | pubmed:author | pubmed-author:LitovchickAA | lld:pubmed |
| pubmed-article:10069377 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10069377 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:10069377 | pubmed:volume | 445 | lld:pubmed |
| pubmed-article:10069377 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10069377 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10069377 | pubmed:pagination | 73-9 | lld:pubmed |
| pubmed-article:10069377 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:10069377 | pubmed:meshHeading | pubmed-meshheading:10069377... | lld:pubmed |
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| pubmed-article:10069377 | pubmed:meshHeading | pubmed-meshheading:10069377... | lld:pubmed |
| pubmed-article:10069377 | pubmed:meshHeading | pubmed-meshheading:10069377... | lld:pubmed |
| pubmed-article:10069377 | pubmed:meshHeading | pubmed-meshheading:10069377... | lld:pubmed |
| pubmed-article:10069377 | pubmed:meshHeading | pubmed-meshheading:10069377... | lld:pubmed |
| pubmed-article:10069377 | pubmed:meshHeading | pubmed-meshheading:10069377... | lld:pubmed |
| pubmed-article:10069377 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10069377 | pubmed:articleTitle | Arginine-aminoglycoside conjugates that bind to HIV transactivation responsive element RNA in vitro. | lld:pubmed |
| pubmed-article:10069377 | pubmed:affiliation | Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot, Israel. | lld:pubmed |
| pubmed-article:10069377 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10069377 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10069377 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10069377 | lld:pubmed |
