|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1999-4-13
|
|
pubmed:abstractText |
Uncoupling protein-2 (UCP2) is a novel mitochondrial protein that may be involved in the control of energy expenditure. We have previously reported an upregulation of adipose tissue UCP2 mRNA expression during fasting in humans. Analysis of changes in metabolic parameters suggested that fatty acids may be associated with the increased UCP2 mRNA level. Culture of human adipose tissue explants was used to study in vitro regulation of adipocyte UCP2 gene expression. A 48-h treatment with BRL49653 and bromopalmitate, two potent activators of PPARgamma, resulted in a dose-dependent increase in UCP2 mRNA levels. The induction by BRL49653 was rapid (from 6 h) and maintained up to 5 days. TNFalpha provoked a 2-fold decrease in UCP2 mRNA levels. Human recombinant leptin did not affect UCP2 mRNA expression. The data support the hypothesis that fatty acids are involved in the control of adipocyte UCP2 mRNA expression in humans.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-bromopalmitate,
http://linkedlifedata.com/resource/pubmed/chemical/Ion Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Leptin,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitochondrial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Palmitates,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazolidinediones,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/ciglitazone,
http://linkedlifedata.com/resource/pubmed/chemical/mitochondrial uncoupling protein 2,
http://linkedlifedata.com/resource/pubmed/chemical/rosiglitazone
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0006-291X
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Copyright 1999 Academic Press.
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
5
|
|
pubmed:volume |
256
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
138-41
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:10066437-Adipocytes,
pubmed-meshheading:10066437-Adipose Tissue,
pubmed-meshheading:10066437-Adult,
pubmed-meshheading:10066437-Cells, Cultured,
pubmed-meshheading:10066437-Culture Techniques,
pubmed-meshheading:10066437-Dose-Response Relationship, Drug,
pubmed-meshheading:10066437-Female,
pubmed-meshheading:10066437-Gene Expression Regulation,
pubmed-meshheading:10066437-Humans,
pubmed-meshheading:10066437-Ion Channels,
pubmed-meshheading:10066437-Leptin,
pubmed-meshheading:10066437-Membrane Transport Proteins,
pubmed-meshheading:10066437-Middle Aged,
pubmed-meshheading:10066437-Mitochondrial Proteins,
pubmed-meshheading:10066437-Palmitates,
pubmed-meshheading:10066437-Proteins,
pubmed-meshheading:10066437-RNA, Messenger,
pubmed-meshheading:10066437-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:10066437-Thiazoles,
pubmed-meshheading:10066437-Thiazolidinediones,
pubmed-meshheading:10066437-Time Factors,
pubmed-meshheading:10066437-Transcription Factors,
pubmed-meshheading:10066437-Transcriptional Activation,
pubmed-meshheading:10066437-Tumor Necrosis Factor-alpha
|
|
pubmed:year |
1999
|
|
pubmed:articleTitle |
Increase in uncoupling protein-2 mRNA expression by BRL49653 and bromopalmitate in human adipocytes.
|
|
pubmed:affiliation |
INSERM Unit 317, Louis Bugnard Institute, Rangueil Hospital, Paul Sabatier University, Toulouse cedex 4, 31403, France.
|
|
pubmed:publicationType |
Journal Article
|
