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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1999-5-4
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pubmed:abstractText |
Mycophenolate mofetil (MMF) is used for immunosuppression after renal transplantation because it reduces lymphocyte proliferation by inhibiting inosine monophosphate dehydrogenase (IMPDH) in lymphocytes and GTP biosynthesis. In the present study we asked if therapeutic concentrations of MMF might interfere with mesangial cell (MC) proliferation which is involved in inflammatory proliferative glomerular diseases.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0931-0509
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
58-63
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10052478-Animals,
pubmed-meshheading:10052478-Apoptosis,
pubmed-meshheading:10052478-Calcium,
pubmed-meshheading:10052478-Cell Division,
pubmed-meshheading:10052478-Cells, Cultured,
pubmed-meshheading:10052478-Culture Media, Serum-Free,
pubmed-meshheading:10052478-Cytosol,
pubmed-meshheading:10052478-Glomerular Mesangium,
pubmed-meshheading:10052478-Guanosine,
pubmed-meshheading:10052478-Humans,
pubmed-meshheading:10052478-IMP Dehydrogenase,
pubmed-meshheading:10052478-Iliac Artery,
pubmed-meshheading:10052478-Immunosuppressive Agents,
pubmed-meshheading:10052478-Lysophospholipids,
pubmed-meshheading:10052478-Muscle, Smooth, Vascular,
pubmed-meshheading:10052478-Mycophenolic Acid,
pubmed-meshheading:10052478-Necrosis,
pubmed-meshheading:10052478-Platelet-Derived Growth Factor,
pubmed-meshheading:10052478-Rats
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pubmed:year |
1999
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pubmed:articleTitle |
Mycophenolate mofetil inhibits rat and human mesangial cell proliferation by guanosine depletion.
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pubmed:affiliation |
Department of Nephrology, University of Frankfurt/Main, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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