Linked Life Data

10051243

Source:http://linkedlifedata.com/resource/pubmed/id/10051243

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1999-4-1
pubmed:abstractText
Alveolar ventilation and CO2 elimination during mechanical ventilation can be enhanced by reducing dead-space ventilation. Aspiration of gas from the dead space (ASPIDS) is a new principle, according to which gas rich in CO2 during late expiration is aspirated through a channel ending at the distal end of the tracheal tube. Simultaneously, fresh gas injected into the inspiratory line fills the airway down to the same site. We hypothesized that ASPIDS would allow a reduction of tidal volume (VT) and airway pressure (Paw). To test our hypothesis we studied six anaesthetized and mechanically ventilated pigs (24 +/- 4 kg). The intention was to decrease VT while keeping PaCO2 constant by using ASPIDS. VT was reduced by decreasing the minute ventilation (V E) in two steps, of 1.8 L/min (VE - 1.8) and 2.2 L/min (VE - 2.2), respectively, and by increasing respiratory rate (RR) from 20 to 46 breaths/min. At ASPIDS, peak Paw was reduced by 35% at VE - 1.8 and at VE - 2.2 (p < 0.001), and by 20% at an RR of 46 (p < 0.01). PaCO2 was maintained or reduced at ASPIDS. No intrinsic positive end-expiratory pressure developed. Arterial blood pressure and heart rate were unaffected. The results show that ASPIDS allows a reduction in VT and Paw while PaCO2 is kept constant. ASPIDS does not lead to problems associated with jet streams of gas or with gas humidification, and can be developed as a safe technique.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1073-449X
pubmed:author
pubmed:issnType
Print
pubmed:volume
159
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
728-32
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Aspiration of airway dead space. A new method to enhance CO2 elimination.
pubmed:affiliation
Departments of Clinical Physiology and Anaesthesia and Intensive Care, University Hospital of Lund, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't