| pubmed-article:10051206 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10051206 | lifeskim:mentions | umls-concept:C0001811 | lld:lifeskim |
| pubmed-article:10051206 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:10051206 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:10051206 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:10051206 | lifeskim:mentions | umls-concept:C0140079 | lld:lifeskim |
| pubmed-article:10051206 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:10051206 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:10051206 | lifeskim:mentions | umls-concept:C0202220 | lld:lifeskim |
| pubmed-article:10051206 | lifeskim:mentions | umls-concept:C1515926 | lld:lifeskim |
| pubmed-article:10051206 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:10051206 | pubmed:dateCreated | 1999-4-26 | lld:pubmed |
| pubmed-article:10051206 | pubmed:abstractText | Ageing in mammals is characterized by a decline in plasma levels of insulin-like growth factor-1 that appears to contribute to both structural and functional changes in a number of tissues. Although insulin-like growth factor-1 has been shown to provide trophic support for neurons and administration of insulin-like growth factor-1 to ageing animals reverses some aspects of brain ageing, age-related changes in insulin-like growth factor-1 or type 1 insulin-like growth factor receptors in brain have not been well documented. In this series of studies, insulin-like growth factor-1 messenger RNA and protein concentrations, and type 1 insulin-like growth factor receptor levels were analysed in young (three to four- and 10-12-month-old), middle-aged (19-20-month-old) and old (29-32-month-old) Fisher 344 x Brown Norway rats. Localization of insulin-like growth factor-1 messenger RNA throughout the lifespan revealed that expression was greatest in arteries, arterioles, and arteriolar anastomoses with greater than 80% of these vessels producing insulin-like growth factor-1 messenger RNA. High levels of expression were also noted in the meninges. No age-related changes were detected by either in situ hybridization or quantitative dot blot analysis of cortical tissue. However, analysis of insulin-like growth factor-1 protein levels in cortex analysed after saline perfusion indicated a 36.5% decrease between 11 and 32 months-of-age (P<0.05). Similarly, analysis of type 1 insulin-like growth factor receptor messenger RNA revealed no changes with age but levels of type 1 insulin-like growth factor receptors indicated a substantial decrease with age (31% in hippocampus and 20.8 and 27.3% in cortical layers II/III and V/VI, respectively). Our results indicate that (i) vasculature and meninges are an important source of insulin-like growth factor-1 for the brain and that expression continues throughout life, (ii) there are no changes in insulin-like growth factor-1 gene expression with age but insulin-like growth factor-1 protein levels decrease suggesting that translational deficiencies or deficits in the transport of insulin-like growth factor-1 through the blood-brain barrier contribute to the decline in brain insulin-like growth factor-1 with age, and (iii) type 1 insulin-like growth factor receptor messenger RNA is unchanged with age but type 1 insulin-like growth factor receptors decrease in several brain regions. We conclude that significant perturbations occur in the insulin-like growth factor-1 axis with age. Since other studies suggest that i.c.v. administration of insulin-like growth factor-1 reverses functional and cognitive deficiencies with age, alterations within the insulin-like growth factor-1 axis may be an important contributing factor in brain ageing. | lld:pubmed |
| pubmed-article:10051206 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10051206 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10051206 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10051206 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10051206 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10051206 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10051206 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10051206 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10051206 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:10051206 | pubmed:issn | 0306-4522 | lld:pubmed |
| pubmed-article:10051206 | pubmed:author | pubmed-author:KhanA SAS | lld:pubmed |
| pubmed-article:10051206 | pubmed:author | pubmed-author:Brunso-Bechto... | lld:pubmed |
| pubmed-article:10051206 | pubmed:author | pubmed-author:McShaneTT | lld:pubmed |
| pubmed-article:10051206 | pubmed:author | pubmed-author:BennettS ASA | lld:pubmed |
| pubmed-article:10051206 | pubmed:author | pubmed-author:LynchC DCD | lld:pubmed |
| pubmed-article:10051206 | pubmed:author | pubmed-author:SonntagW EWE | lld:pubmed |
| pubmed-article:10051206 | pubmed:author | pubmed-author:IngramR LRL | lld:pubmed |
| pubmed-article:10051206 | pubmed:author | pubmed-author:CooneyP TPT | lld:pubmed |
| pubmed-article:10051206 | pubmed:author | pubmed-author:ThorntonP LPL | lld:pubmed |
| pubmed-article:10051206 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10051206 | pubmed:volume | 88 | lld:pubmed |
| pubmed-article:10051206 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10051206 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10051206 | pubmed:pagination | 269-79 | lld:pubmed |
| pubmed-article:10051206 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:10051206 | pubmed:meshHeading | pubmed-meshheading:10051206... | lld:pubmed |
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| pubmed-article:10051206 | pubmed:meshHeading | pubmed-meshheading:10051206... | lld:pubmed |
| pubmed-article:10051206 | pubmed:meshHeading | pubmed-meshheading:10051206... | lld:pubmed |
| pubmed-article:10051206 | pubmed:meshHeading | pubmed-meshheading:10051206... | lld:pubmed |
| pubmed-article:10051206 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10051206 | pubmed:articleTitle | Alterations in insulin-like growth factor-1 gene and protein expression and type 1 insulin-like growth factor receptors in the brains of ageing rats. | lld:pubmed |
| pubmed-article:10051206 | pubmed:affiliation | Department of Physiology and Pharmacology and the Sticht Center on Ageing, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1083, USA. | lld:pubmed |
| pubmed-article:10051206 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10051206 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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