Linked Life Data

10050919

Source:http://linkedlifedata.com/resource/pubmed/id/10050919

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-3
pubmed:dateCreated
1999-5-4
pubmed:abstractText
The recent Expert Consultation of World Health Organization (WHO)/Food and Agricultural Organization (FAO)/International Atomic Energy Agency (IAEA) defined essentiality of a trace element as follows: "An element is considered essential to an organism when reduction of its exposure below a certain limit results consistently in a reduction in a physiologically important function, or when the element is an integral part of an organic structure performing a vital function in the organism." This definition omits a previous postulate that the mechanism of action of an essential trace element should be well defined; it also supersedes another criterion, once suggested for essentiality, a normal, rather than log-normal distribution of an element's tissue concentrations. The Expert Consultation offers no generally applicable criteria for the physiological importance of functions, and that determination is left to expert groups charged with setting national and other nutritional recommendations. The use of the term "physiological" rather than "biochemical" strongly implies that neither changes of an element's concentration nor of a specific enzyme function alone are proof of essentiality. Among physiologically important functions are growth, reproduction, longevity, and all metabolic and hormonal functions that bear a clear, inverse relation to disease risk. Finally, the term "consistent" states the need for independent confirmation of the original data, before an element can be recognized as essential. These definitions will be discussed as background for further discussions of our present knowledge of boron (B).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0163-4984
pubmed:author
pubmed:issnType
Print
pubmed:volume
66
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
185-91
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Review of the scientific basis for establishing the essentiality of trace elements.
pubmed:publicationType
Journal Article, Review