|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1999-8-17
|
|
pubmed:abstractText |
The role of the possible retrograde messenger nitric oxide (NO) in the induction of long-term potentiation (LTP) was studied in supragranular layers of somatosensory cortical slices obtained from adult mice. High-frequency stimulation produced a slowly rising, long-lasting (50 min) and significant (P < 0.001) increase in the extracellular synaptic response by 23%. The induction of LTP was independent from activation of N-methyl-D-aspartate (NMDA) receptors, but prevented by bath application of NG-nitro-L-arginine methyl ester (L-NAME), indicating that one or several of the different NO synthases (NOS) produced NO within the postsynaptic neuron. No LTP could be induced in knockout mice lacking the endothelial NOS (eNOS) isoform. These data suggest that eNOS is involved in an NMDA receptor-independent form of LTP in the rodent cerebral cortex.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2-Amino-5-phosphonovalerate,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/NG-Nitroarginine Methyl Ester,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type III,
http://linkedlifedata.com/resource/pubmed/chemical/Nos3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0022-3077
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
81
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
494-7
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:10036253-2-Amino-5-phosphonovalerate,
pubmed-meshheading:10036253-Animals,
pubmed-meshheading:10036253-Electric Stimulation,
pubmed-meshheading:10036253-Enzyme Inhibitors,
pubmed-meshheading:10036253-Evoked Potentials,
pubmed-meshheading:10036253-Excitatory Amino Acid Antagonists,
pubmed-meshheading:10036253-Long-Term Potentiation,
pubmed-meshheading:10036253-Mice,
pubmed-meshheading:10036253-Mice, Knockout,
pubmed-meshheading:10036253-NG-Nitroarginine Methyl Ester,
pubmed-meshheading:10036253-Neocortex,
pubmed-meshheading:10036253-Neuronal Plasticity,
pubmed-meshheading:10036253-Nitric Oxide Synthase,
pubmed-meshheading:10036253-Nitric Oxide Synthase Type II,
pubmed-meshheading:10036253-Nitric Oxide Synthase Type III,
pubmed-meshheading:10036253-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:10036253-Somatosensory Cortex,
pubmed-meshheading:10036253-Synaptic Transmission
|
|
pubmed:year |
1999
|
|
pubmed:articleTitle |
Impairment of neocortical long-term potentiation in mice deficient of endothelial nitric oxide synthase.
|
|
pubmed:affiliation |
Institute of Neurophysiology, University of Düsseldorf, D-40001 Dusseldorf, Germany.
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|
