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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1999-3-16
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pubmed:abstractText |
The formation of a persistently active cAMP-dependent protein kinase (PKA) is critical for establishing long-term synaptic facilitation (LTF) in Aplysia. The injection of bovine catalytic (C) subunits into sensory neurons is sufficient to produce protein synthesis-dependent LTF. Early in the LTF induced by serotonin (5-HT), an autonomous PKA is generated through the ubiquitin-proteasome-mediated proteolysis of regulatory (R) subunits. The degradation of R occurs during an early time window and appears to be a key function of proteasomes in LTF. Lactacystin, a specific proteasome inhibitor, blocks the facilitation induced by 5-HT, and this block is rescued by injecting C subunits. R is degraded through an allosteric mechanism requiring an elevation of cAMP coincident with the induction of a ubiquitin carboxy-terminal hydrolase.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0896-6273
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
147-56
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:10027297-Animals,
pubmed-meshheading:10027297-Aplysia,
pubmed-meshheading:10027297-Cattle,
pubmed-meshheading:10027297-Cyclic AMP,
pubmed-meshheading:10027297-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:10027297-Cysteine Endopeptidases,
pubmed-meshheading:10027297-Injections,
pubmed-meshheading:10027297-Long-Term Potentiation,
pubmed-meshheading:10027297-Multienzyme Complexes,
pubmed-meshheading:10027297-Neurons, Afferent,
pubmed-meshheading:10027297-Peptide Fragments,
pubmed-meshheading:10027297-Proteasome Endopeptidase Complex,
pubmed-meshheading:10027297-Serotonin,
pubmed-meshheading:10027297-Ubiquitins
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pubmed:year |
1999
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pubmed:articleTitle |
Mechanisms for generating the autonomous cAMP-dependent protein kinase required for long-term facilitation in Aplysia.
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pubmed:affiliation |
Center for Neurobiology and Behavior, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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