The adenomatous polyposis coli (APC) tumor suppressor protein is inactivated by mutations in the majority of colorectal cancers. A recent study has revealed that alterations in the APC signaling pathway can result in the transcriptional activation of the c-MYC gene.
Division of Molecular Medicine and Genetics, Department of Internal Medicine, Human Genetics, University of Michigan Cancer Center, Ann Arbor, 48109-0638 USA. fearon@umich.edu
