9990463

Source:http://linkedlifedata.com/resource/pubmed/id/9990463

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0034140, umls-concept:C0205250, umls-concept:C0243077, umls-concept:C1332721, umls-concept:C2698650
pubmed:issue	1
pubmed:dateCreated	1999-4-13
pubmed:abstractText	Novel 2,6,9-substituted purine derivatives represent a class of potent and selective inhibitors of CDK1/cyclinB. The synthesis, SAR and biological profile of selected compounds are described.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents, http://linkedlifedata.com/resource/pubmed/chemical/CDC2 Protein Kinase, http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP-Dependent Protein Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Epidermal Growth Factor, http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes, http://linkedlifedata.com/resource/pubmed/chemical/Kinetin, http://linkedlifedata.com/resource/pubmed/chemical/PRKCA protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C, http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C-alpha, http://linkedlifedata.com/resource/pubmed/chemical/Purines, http://linkedlifedata.com/resource/pubmed/chemical/olomoucine
pubmed:status	MEDLINE
pubmed:month	Jan
pubmed:issn	0960-894X
pubmed:author	pubmed-author:CapraroH GHG, pubmed-author:FurerRR, pubmed-author:ImbachPP, pubmed-author:MetzNN, pubmed-author:MeyerTT, pubmed-author:ZimmermannJJ
pubmed:issnType	Print
pubmed:day	4
pubmed:volume	9
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	91-6
pubmed:dateRevised	2009-11-19
pubmed:meshHeading	pubmed-meshheading:9990463-Antineoplastic Agents, pubmed-meshheading:9990463-CDC2 Protein Kinase, pubmed-meshheading:9990463-Cyclic AMP-Dependent Protein Kinases, pubmed-meshheading:9990463-Enzyme Inhibitors, pubmed-meshheading:9990463-Epidermal Growth Factor, pubmed-meshheading:9990463-Humans, pubmed-meshheading:9990463-Isoenzymes, pubmed-meshheading:9990463-Kinetin, pubmed-meshheading:9990463-Protein Kinase C, pubmed-meshheading:9990463-Protein Kinase C-alpha, pubmed-meshheading:9990463-Purines, pubmed-meshheading:9990463-Structure-Activity Relationship
pubmed:year	1999
pubmed:articleTitle	2,6,9-trisubstituted purines: optimization towards highly potent and selective CDK1 inhibitors.
pubmed:affiliation	Novartis Pharmaceuticals, Novartis Limited, Basel, Switzerland.
pubmed:publicationType	Journal Article