|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0205314,
umls-concept:C0205460,
umls-concept:C0220781,
umls-concept:C0243071,
umls-concept:C0360703,
umls-concept:C0376249,
umls-concept:C0439857,
umls-concept:C0441655,
umls-concept:C0675017,
umls-concept:C0679622,
umls-concept:C1555029,
umls-concept:C1883254
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1999-4-13
|
|
pubmed:abstractText |
A series of 3,4-dimethoxyphenethylamine derivatives was prepared, and their prolongation effects on effective refractory period of contractile response (ERPc) and action potential duration (APD) in isolated guinea-pig papillary muscles at 1 Hz and 3 Hz were examined. SAR studies led to the identification of KCB-328 (51) which is a novel class III antiarrhythmic agent with little reverse frequency dependence.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
pubmed-author:ChungY SYS,
pubmed-author:JeonG HGH,
pubmed-author:JungK YKY,
pubmed-author:KimD IDI,
pubmed-author:KozonoTT,
pubmed-author:KwonL SLS,
pubmed-author:LawK AKA,
pubmed-author:LeeKK,
pubmed-author:LiuK TKT,
pubmed-author:NamW HWH,
pubmed-author:ParkS DSD,
pubmed-author:TanabeSS
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
4
|
|
pubmed:volume |
9
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
85-90
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:9990462-Animals,
pubmed-meshheading:9990462-Anti-Arrhythmia Agents,
pubmed-meshheading:9990462-Drug Evaluation, Preclinical,
pubmed-meshheading:9990462-Guinea Pigs,
pubmed-meshheading:9990462-Muscle Contraction,
pubmed-meshheading:9990462-Myocardial Contraction,
pubmed-meshheading:9990462-Papillary Muscles,
pubmed-meshheading:9990462-Phenethylamines,
pubmed-meshheading:9990462-Structure-Activity Relationship,
pubmed-meshheading:9990462-Sulfonamides
|
|
pubmed:year |
1999
|
|
pubmed:articleTitle |
Synthesis and biological activity of KCB-328 and its analogues: novel class III antiarrhythmic agents with little reverse frequency dependence.
|
|
pubmed:affiliation |
C&C Research Laboratories, Kyunggi-do, Korea.
|
|
pubmed:publicationType |
Journal Article,
In Vitro
|
