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rdf:type |
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lifeskim:mentions |
umls-concept:C0000392,
umls-concept:C0205147,
umls-concept:C0205314,
umls-concept:C0205460,
umls-concept:C0220781,
umls-concept:C0220825,
umls-concept:C0243071,
umls-concept:C0257217,
umls-concept:C0392747,
umls-concept:C0679622,
umls-concept:C1554963,
umls-concept:C1883254
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|
pubmed:issue |
1
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|
pubmed:dateCreated |
1999-4-13
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|
pubmed:abstractText |
Structure modification of the beta-alanine region (fragment C) of the potent antimitotic agent cryptophycin was investigated. This includes: (1) introduction of substituents at the previously unsubstituted C7 position of the macrolide ring and (2) replacement of the (2R)-3-amino-2-methyl-propanoic acid (beta-alanine) with various (1)-amino acids to give the corresponding 15-membered unnatural cryptophycin analogs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0960-894X
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
4
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
69-74
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:9990459-Amino Acid Substitution,
pubmed-meshheading:9990459-Animals,
pubmed-meshheading:9990459-Antineoplastic Agents,
pubmed-meshheading:9990459-Carcinoma,
pubmed-meshheading:9990459-Colonic Neoplasms,
pubmed-meshheading:9990459-Depsipeptides,
pubmed-meshheading:9990459-Dose-Response Relationship, Drug,
pubmed-meshheading:9990459-Drug Screening Assays, Antitumor,
pubmed-meshheading:9990459-Humans,
pubmed-meshheading:9990459-Mice,
pubmed-meshheading:9990459-Models, Molecular,
pubmed-meshheading:9990459-Pancreatic Neoplasms,
pubmed-meshheading:9990459-Peptides, Cyclic,
pubmed-meshheading:9990459-Protein Conformation,
pubmed-meshheading:9990459-Structure-Activity Relationship,
pubmed-meshheading:9990459-Tumor Cells, Cultured,
pubmed-meshheading:9990459-beta-Alanine
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pubmed:year |
1999
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pubmed:articleTitle |
Synthesis and biological evaluation of novel cryptophycin analogs with modification in the beta-alanine region.
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pubmed:affiliation |
Lilly Research Laboratories, Indianapolis, IN 46285, USA.
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pubmed:publicationType |
Journal Article
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