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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1999-3-4
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pubmed:abstractText |
Patients with peripheral arterial disease (PAD) have exercise limitation due to claudication-limited pain and metabolic alterations in skeletal muscle. PAD is also associated with oxidative stress, which is a known cause of mitochondrial DNA (mtDNA) injury. The present study was designed to test the hypothesis that PAD is associated with mtDNA injury, as reflected by an increased frequency of a specific 4977-base pair (bp) mtDNA deletion mutation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0009-7322
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
99
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
807-12
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pubmed:dateRevised |
2010-3-24
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pubmed:meshHeading |
pubmed-meshheading:9989967-Aged,
pubmed-meshheading:9989967-Aging,
pubmed-meshheading:9989967-Citrate (si)-Synthase,
pubmed-meshheading:9989967-DNA, Mitochondrial,
pubmed-meshheading:9989967-DNA Mutational Analysis,
pubmed-meshheading:9989967-Electron Transport Complex IV,
pubmed-meshheading:9989967-Energy Metabolism,
pubmed-meshheading:9989967-Gene Deletion,
pubmed-meshheading:9989967-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:9989967-Humans,
pubmed-meshheading:9989967-Intermittent Claudication,
pubmed-meshheading:9989967-Male,
pubmed-meshheading:9989967-Middle Aged,
pubmed-meshheading:9989967-Mitochondria,
pubmed-meshheading:9989967-Muscle, Skeletal,
pubmed-meshheading:9989967-Peripheral Vascular Diseases
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pubmed:year |
1999
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pubmed:articleTitle |
Skeletal muscle mitochondrial DNA injury in patients with unilateral peripheral arterial disease.
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pubmed:affiliation |
Department of Medicine, Harbor-UCLA Medical Center, Torrance, Calif. 90509, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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