Linked Life Data

9988439

Source:http://linkedlifedata.com/resource/pubmed/id/9988439

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1999-4-23
pubmed:abstractText
Positional cloning has been applied successfully to many Mendelian disorders. Because of the public health significance, there is strong interest in mapping susceptibility genes for common disorders, such as asthma and allergy, that have a genetic component. Genome-wide screening has been very useful in detecting regions of the genome likely to contain susceptibility genes. There are multiple chromosomal regions implicated in asthma and now the difficult process of finding the genes and relevant mutations is underway. Two approaches that are being utilized are those of association studies in candidate genes, and haplotype sharing or identical by descent (IBD) mapping. Although these are useful approaches, it is important to realize the strengths and limitations of each. The level of significance needed for an initial study or a replication study should be considered in light of the prior evidence for studying a specific gene polymorphism. Haplotype-sharing approaches, although difficult to use in outbred heterogeneous populations, may provide important insight into fine mapping and gene localization.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0954-7894
pubmed:author
pubmed:issnType
Print
pubmed:volume
28 Suppl 5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-5; discussion 26-8
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Genetics of complex human diseases: genome screening, association studies and fine mapping.
pubmed:affiliation
Center for the Genetics of Asthma and Complex Diseases, University of Maryland School of Medicine, Baltimore 21201, USA.
pubmed:publicationType
Journal Article, Review