Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1999-4-15
|
| pubmed:abstractText |
Hepatocyte growth factor (HGF) and its c-met receptor comprise a signaling system that has been implicated in tissue repair and regeneration. HGF action is specifically targeted to the damaged organ following injury; however, the mechanism underlying this important targeting process remains to be elucidated. We reasoned that induction of c-met expression might be a critical factor in determining the site specificity of this receptor-ligand system. To test this hypothesis, we examined changes in activity of the HGF/c-met system in the folic acid model of acute tubular injury and repair.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0085-2538
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
55
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
442-53
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:9987069-Acute Kidney Injury,
pubmed-meshheading:9987069-Animals,
pubmed-meshheading:9987069-Cell Division,
pubmed-meshheading:9987069-Cells, Cultured,
pubmed-meshheading:9987069-Epithelial Cells,
pubmed-meshheading:9987069-Gene Amplification,
pubmed-meshheading:9987069-Gene Expression Regulation,
pubmed-meshheading:9987069-Gene Targeting,
pubmed-meshheading:9987069-Hepatocyte Growth Factor,
pubmed-meshheading:9987069-Kidney,
pubmed-meshheading:9987069-Male,
pubmed-meshheading:9987069-Promoter Regions, Genetic,
pubmed-meshheading:9987069-Proto-Oncogene Proteins c-met,
pubmed-meshheading:9987069-RNA, Messenger,
pubmed-meshheading:9987069-Rats,
pubmed-meshheading:9987069-Rats, Sprague-Dawley,
pubmed-meshheading:9987069-Transcription, Genetic,
pubmed-meshheading:9987069-Up-Regulation
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Up-regulation of hepatocyte growth factor receptor: an amplification and targeting mechanism for hepatocyte growth factor action in acute renal failure.
|
| pubmed:affiliation |
Department of Medicine, Rhode Island Hospital, Brown University School of Medicine, Providence, Rhode Island, USA. Yliu@lifespan.org
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|