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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1999-4-1
|
| pubmed:abstractText |
Amyloid beta-peptide (A beta), the major constituent of the senile plaques in the brains of patients with Alzheimer's disease, is cytotoxic to neurons and has a central role in the pathogenesis of the disease. Previous studies have suggested that oxidative stress is involved in the mechanisms of A beta-induced neurotoxicity in vitro. In the present study, we examined whether oxidative stress contributes to learning and memory deficits caused by continuous intracerebroventricular infusion of A beta-(1-42). In the A beta-(1-42)-infused rats, spontaneous alternation behaviour in a Y-maze and spatial memory in a water maze task were significantly impaired, as compared with A beta-(40-1)-infused control rats. The retention of passive avoidance learning was also significantly impaired by treatment with A beta-(1-42). Potent antioxidants idebenone and alpha-tocopherol prevented the behavioural deficits in Y-maze and water maze, but not passive avoidance, tasks in A beta-(1-42)-infused rats when they were repeatedly administered by mouth once a day from 3 days before the start of A beta infusion to the end of behavioural experiments. Lipid peroxide levels in the hippocampus and cerebral cortex of A beta-(1-42)-infused rats did not differ from those in control animals, and neither idebenone nor alpha-tocopherol affected the lipid peroxide levels. These results suggest that treatment with antioxidants such as idebenone and alpha-tocopherol prevents learning and memory deficits caused by A beta.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amyloid beta-Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Benzoquinones,
http://linkedlifedata.com/resource/pubmed/chemical/Neurotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Ubiquinone,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamin E,
http://linkedlifedata.com/resource/pubmed/chemical/amyloid beta-protein (1-42),
http://linkedlifedata.com/resource/pubmed/chemical/idebenone
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0953-816X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
11
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
83-90
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:9987013-Alzheimer Disease,
pubmed-meshheading:9987013-Amyloid beta-Peptides,
pubmed-meshheading:9987013-Animals,
pubmed-meshheading:9987013-Antioxidants,
pubmed-meshheading:9987013-Avoidance Learning,
pubmed-meshheading:9987013-Benzoquinones,
pubmed-meshheading:9987013-Brain Chemistry,
pubmed-meshheading:9987013-Drug Interactions,
pubmed-meshheading:9987013-Injections, Intraventricular,
pubmed-meshheading:9987013-Lipid Peroxidation,
pubmed-meshheading:9987013-Locomotion,
pubmed-meshheading:9987013-Male,
pubmed-meshheading:9987013-Maze Learning,
pubmed-meshheading:9987013-Memory,
pubmed-meshheading:9987013-Nerve Degeneration,
pubmed-meshheading:9987013-Neurotoxins,
pubmed-meshheading:9987013-Oxidative Stress,
pubmed-meshheading:9987013-Peptide Fragments,
pubmed-meshheading:9987013-Rats,
pubmed-meshheading:9987013-Rats, Wistar,
pubmed-meshheading:9987013-Ubiquinone,
pubmed-meshheading:9987013-Vitamin E
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Protective effects of idebenone and alpha-tocopherol on beta-amyloid-(1-42)-induced learning and memory deficits in rats: implication of oxidative stress in beta-amyloid-induced neurotoxicity in vivo.
|
| pubmed:affiliation |
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University School of Medicine, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|