Linked Life Data

9974411

Source:http://linkedlifedata.com/resource/pubmed/id/9974411

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1999-3-16
pubmed:abstractText
The common C-480T transition in the hepatic lipase (HL) promoter has been shown to be associated with lower HL activity and increased high density lipoprotein (HDL) cholesterol. We examined the frequency and lipid associations of this HL polymorphism in 385 healthy, young (18- to 28-year-old) men whose fathers had had a premature myocardial infarction (designated cases) and 405 age-matched controls. These individuals were participants in the European Atherosclerosis Research Study II postprandial trial, who had been recruited from 11 European countries in 4 regions (the Baltic; United Kingdom; and central and southern Europe). Overall, the frequency of the T allele was 0.207 in controls and 0.244 in cases (P=0.08). The T allele was associated with higher fasting plasma total cholesterol (P<0.01), triglycerides (P<0.01), and HDL cholesterol (P<0.01). The strongest association was found with apolipoprotein (apo) A-I concentration, which was 10% higher in individuals homozygous for the T allele compared with those homozygous for the C allele (P<0.001). This polymorphism had no effect on the rise in plasma triglyceride levels after a fatty meal. However, before and after the fat load was ingested, levels of particles containing both apoC-III and apoB (LpC-III:B) were higher in carriers of the T allele, with homozygotes having 23% and 27% higher levels preprandially and postprandially, respectively, than those homozygous for the C allele (P<0.05). Thus, our results demonstrate that the C-480T polymorphism in the HL promoter is associated with alterations in plasma lipids and lipoproteins and the accumulation of atherogenic LpC-III:B particles.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1079-5642
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
303-8
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:9974411-Adolescent, pubmed-meshheading:9974411-Adult, pubmed-meshheading:9974411-Alleles, pubmed-meshheading:9974411-Apolipoprotein C-III, pubmed-meshheading:9974411-Apolipoproteins, pubmed-meshheading:9974411-Apolipoproteins B, pubmed-meshheading:9974411-Apolipoproteins C, pubmed-meshheading:9974411-Cholesterol, HDL, pubmed-meshheading:9974411-Eating, pubmed-meshheading:9974411-Fasting, pubmed-meshheading:9974411-Genetic Variation, pubmed-meshheading:9974411-Humans, pubmed-meshheading:9974411-Lipase, pubmed-meshheading:9974411-Lipids, pubmed-meshheading:9974411-Lipoproteins, pubmed-meshheading:9974411-Liver, pubmed-meshheading:9974411-Male, pubmed-meshheading:9974411-Polymorphism, Genetic, pubmed-meshheading:9974411-Promoter Regions, Genetic, pubmed-meshheading:9974411-Triglycerides
pubmed:year
1999
pubmed:articleTitle
The T allele of the hepatic lipase promoter variant C-480T is associated with increased fasting lipids and HDL and increased preprandial and postprandial LpCIII:B : European Atherosclerosis Research Study (EARS) II.
pubmed:affiliation
Department of Internal Medicine III and Biochemistry, Erasmus University, Rotterdam, The Netherlands. jansen@bc1.fgg.eur.nl
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't