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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1999-5-27
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pubmed:abstractText |
In this study we prospectively assessed the reliability of a new fibrin monomer assay in 106 outpatients with clinically suspected deep venous thrombosis of the lower limb. According to the results of the objective tests and using different cut-off points we calculated the sensitivity, specificity and negative predictive value of the fibrin monomer assay. The prevalence of deep vein thrombosis was 44.3% (31.1% proximal, 13.2% distal). Using a cut-off level of plasma fibrin monomer of 3.5 microg/ml, a sensitivity, specificity and negative predictive value of 100% (95% CI: 94-100%), 35.6% (95% CI: 23-48%) and 100% (95% CI: 86-100%), respectively, were obtained. The exclusion rate was 19.8% (95% CI: 12-27%) of all referred patients. These accuracy indices compared favourably with the respective results of a routine D-dimer ELISA used for comparison. Conclusion: This new fibrin monomer assay appears to be a reliable method for the exclusion of deep vein thrombosis in symptomatic outpatients.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0340-6245
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
50-3
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9974374-Adolescent,
pubmed-meshheading:9974374-Adult,
pubmed-meshheading:9974374-Aged,
pubmed-meshheading:9974374-Aged, 80 and over,
pubmed-meshheading:9974374-Biological Assay,
pubmed-meshheading:9974374-Female,
pubmed-meshheading:9974374-Fibrin Fibrinogen Degradation Products,
pubmed-meshheading:9974374-Humans,
pubmed-meshheading:9974374-Male,
pubmed-meshheading:9974374-Middle Aged,
pubmed-meshheading:9974374-Predictive Value of Tests,
pubmed-meshheading:9974374-Prospective Studies,
pubmed-meshheading:9974374-Sensitivity and Specificity,
pubmed-meshheading:9974374-Thrombophlebitis
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pubmed:year |
1999
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pubmed:articleTitle |
Performance of a new fibrin monomer assay to exclude deep vein thrombosis in symptomatic outpatients.
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pubmed:affiliation |
Central Hematology Laboratory, University Hospital, Inselspital Bern, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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