| pubmed-article:9973457 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9973457 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:9973457 | lifeskim:mentions | umls-concept:C0029923 | lld:lifeskim |
| pubmed-article:9973457 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:9973457 | lifeskim:mentions | umls-concept:C0241526 | lld:lifeskim |
| pubmed-article:9973457 | lifeskim:mentions | umls-concept:C1539081 | lld:lifeskim |
| pubmed-article:9973457 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:9973457 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:9973457 | lifeskim:mentions | umls-concept:C0205373 | lld:lifeskim |
| pubmed-article:9973457 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:9973457 | pubmed:dateCreated | 1999-4-13 | lld:pubmed |
| pubmed-article:9973457 | pubmed:abstractText | CD40 ligand (CD40L) gene-disrupted (CD40L-/-) mice were employed to examine the role of costimulatory signals via CD40L-CD40 interactions in mucosally induced tolerance. CD40L-/- and control (CD40L+/+) mice of the same C57BL/6 x 129/J background were immunized orally with 25 mg of OVA before systemic challenge with OVA in CFA. While CD40L+/+ mice showed reductions in Ag-specific T cell responses including delayed-type hypersensitivity (DTH) and proliferative responses, CD40L-/- mice underwent normal T cell responses. Further, cytokine analysis of splenic CD4+ T cells showed that both Th1-type (e.g., IFN-gamma and IL-2) and Th2-type (e.g., IL-4, IL-5, IL-6, and IL-10) responses were maintained in CD40L-/- mice orally immunized with OVA, whereas these cytokine responses in CD40L+/+ mice were significantly reduced. In addition, splenic CD4+ T cells from CD40L-/- mice orally immunized with OVA provided B cell help in Ag-specific Ab-forming cells when the cells were cultured with naive B cells in the presence of Ag and CD40L-transfected cell lines. In contrast, an identical culture condition containing splenic CD4+ T cells from orally tolerized CD40L+/+ mice did not exhibit helper activity. Taken together, these findings indicate that CD40L and CD40 interactions are essential for the induction of systemic T cell unresponsiveness to orally administered Ag. | lld:pubmed |
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| pubmed-article:9973457 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9973457 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9973457 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:9973457 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9973457 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:9973457 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:9973457 | pubmed:author | pubmed-author:YamamotoMM | lld:pubmed |
| pubmed-article:9973457 | pubmed:author | pubmed-author:KogaTT | lld:pubmed |
| pubmed-article:9973457 | pubmed:author | pubmed-author:McGheeJ RJR | lld:pubmed |
| pubmed-article:9973457 | pubmed:author | pubmed-author:KiyonoHH | lld:pubmed |
| pubmed-article:9973457 | pubmed:author | pubmed-author:WakatsukiYY | lld:pubmed |
| pubmed-article:9973457 | pubmed:author | pubmed-author:FujihashiKK | lld:pubmed |
| pubmed-article:9973457 | pubmed:author | pubmed-author:KweonM NMN | lld:pubmed |
| pubmed-article:9973457 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9973457 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:9973457 | pubmed:volume | 162 | lld:pubmed |
| pubmed-article:9973457 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9973457 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9973457 | pubmed:pagination | 1904-9 | lld:pubmed |
| pubmed-article:9973457 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:9973457 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:9973457 | pubmed:articleTitle | Mucosally induced systemic T cell unresponsiveness to ovalbumin requires CD40 ligand-CD40 interactions. | lld:pubmed |
| pubmed-article:9973457 | pubmed:affiliation | Department of Oral Biology, Immunobiology Vaccine Center, University of Alabama Medical Center, Birmingham 35294, USA. | lld:pubmed |
| pubmed-article:9973457 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9973457 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:9973457 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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