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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1999-2-23
|
| pubmed:abstractText |
We conducted this study to evaluate whether there is an association between preoperative drug therapy and in-hospital mortality in patients undergoing coronary artery graft surgery. We collected data on 1593 consecutive patients undergoing coronary artery surgery. The relative risk of in-hospital mortality was determined by logistic regression with in-hospital mortality as the dependent variable, and independent variables that included known risk factors and preoperative cardioactive or antithrombotic drug treatment, i.e., age; left ventricular function; left main coronary artery disease; urgent priority; gender; previous cardiac surgery; concurrent cardiovascular surgery; chronic lung disease; creatinine concentration; hemoglobin concentration; diabetes; hypertension; cerebrovascular disease; recent myocardial infarction; prior vascular surgery; number of arteries bypassed; and regular daily treatment with beta-blockers, aspirin within 5 days, calcium antagonists, angiotensin converting enzyme (ACE) inhibitors, digoxin, or warfarin. In-hospital mortality was 3.3%. The relative risk of in-hospital mortality (with 95% confidence intervals of the relative risk) associated with the following drug treatments was: nitrates 3.8 (1.5-9.6), beta-blockers 0.4 (0.2-0.8), aspirin within 5 days 1.0 (0.5-1.9), calcium antagonists 1.1 (0.6-2.1), ACE inhibitors 0.8 (0.4-1.5), digoxin 0.7 (0.2-1.8), and warfarin 0.3 (0.1-1.6). We conclude that in-hospital mortality is positively associated with preoperative nitrate therapy and negatively associated with beta-adrenergic blocker therapy. A significant association between in-hospital mortality and the preoperative use of calcium antagonists, ACE inhibitors, aspirin, digoxin, and warfarin was not confirmed. Implications: We examined the association between common drug treatments for ischemic heart disease and short-term survival after cardiac surgery using a statistical method to adjust for patients' preoperative medical condition. Death after surgery was more likely after nitrate therapy and less likely after beta-blocker therapy.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin-Converting Enzyme...,
http://linkedlifedata.com/resource/pubmed/chemical/Anticoagulants,
http://linkedlifedata.com/resource/pubmed/chemical/Aspirin,
http://linkedlifedata.com/resource/pubmed/chemical/Cardiotonic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Creatinine,
http://linkedlifedata.com/resource/pubmed/chemical/Digoxin,
http://linkedlifedata.com/resource/pubmed/chemical/Fibrinolytic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Hemoglobins,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrates,
http://linkedlifedata.com/resource/pubmed/chemical/Warfarin
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0003-2999
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
88
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
286-91
|
| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:9972742-Adrenergic beta-Antagonists,
pubmed-meshheading:9972742-Age Factors,
pubmed-meshheading:9972742-Aged,
pubmed-meshheading:9972742-Angiotensin-Converting Enzyme Inhibitors,
pubmed-meshheading:9972742-Anticoagulants,
pubmed-meshheading:9972742-Aspirin,
pubmed-meshheading:9972742-Cardiotonic Agents,
pubmed-meshheading:9972742-Cerebrovascular Disorders,
pubmed-meshheading:9972742-Chronic Disease,
pubmed-meshheading:9972742-Coronary Artery Bypass,
pubmed-meshheading:9972742-Coronary Disease,
pubmed-meshheading:9972742-Creatinine,
pubmed-meshheading:9972742-Diabetes Complications,
pubmed-meshheading:9972742-Digoxin,
pubmed-meshheading:9972742-Female,
pubmed-meshheading:9972742-Fibrinolytic Agents,
pubmed-meshheading:9972742-Forecasting,
pubmed-meshheading:9972742-Hemoglobins,
pubmed-meshheading:9972742-Hospital Mortality,
pubmed-meshheading:9972742-Humans,
pubmed-meshheading:9972742-Hypertension,
pubmed-meshheading:9972742-Logistic Models,
pubmed-meshheading:9972742-Lung Diseases,
pubmed-meshheading:9972742-Male,
pubmed-meshheading:9972742-Middle Aged,
pubmed-meshheading:9972742-Myocardial Infarction,
pubmed-meshheading:9972742-Nitrates,
pubmed-meshheading:9972742-Reoperation,
pubmed-meshheading:9972742-Risk Factors,
pubmed-meshheading:9972742-Sex Factors,
pubmed-meshheading:9972742-Survival Rate,
pubmed-meshheading:9972742-Ventricular Function, Left,
pubmed-meshheading:9972742-Warfarin
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Drug therapy before coronary artery surgery: nitrates are independent predictors of mortality and beta-adrenergic blockers predict survival.
|
| pubmed:affiliation |
Department of Anaesthesia, Sir Charles Gairdner Hospital, Nedlands, Western Australia.
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| pubmed:publicationType |
Journal Article
|