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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1977-1-3
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pubmed:abstractText |
Isoprenaline dose-response curves plotting increases in heart rate before and after labetalol are suggestive of competitive antagonism at beta-adrenoceptor sites. Phenylephrine dose-response curves using increases in systolic pressure before and after labetalol are suggestive of competitive antagonism at alpha-adrenoceptor sites. The ratio of alpha:beta-adrenoceptor antagonism induced by labetalol is approximately 1:3. Peak pharmacological responses after a single oral dose of labetalol (400 mg) occurred between 90-120 min after administration.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9968-13887414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9968-13889121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9968-14089056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9968-186090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9968-238705,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9968-242209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9968-4148916,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9968-4362588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9968-4396864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9968-4404413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9968-4850484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9968-4877600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9968-802650
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0306-5251
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
849-55
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9968-Adrenergic alpha-Antagonists,
pubmed-meshheading:9968-Adrenergic beta-Antagonists,
pubmed-meshheading:9968-Adult,
pubmed-meshheading:9968-Blood Pressure,
pubmed-meshheading:9968-Dose-Response Relationship, Drug,
pubmed-meshheading:9968-Ethanolamines,
pubmed-meshheading:9968-Heart Rate,
pubmed-meshheading:9968-Humans,
pubmed-meshheading:9968-Isoproterenol,
pubmed-meshheading:9968-Labetalol,
pubmed-meshheading:9968-Male,
pubmed-meshheading:9968-Phenylephrine
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pubmed:year |
1976
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pubmed:articleTitle |
Assessment of alpha- and beta-adrenoceptor blocking actions of labetalol.
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pubmed:publicationType |
Journal Article
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