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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1999-3-30
|
| pubmed:abstractText |
The safety and antiviral activity of the second-generation nonnucleoside inhibitor HBY 097 was investigated in asymptomatic or mildly symptomatic human immunodeficiency virus (HIV)-1-infected patients in a randomized, double-blinded, dose-escalation study. Mean maximum virus load decreases ranged from -1.31 log10 copies/mL of plasma at week 1 in the group receiving HBY 097 monotherapy (250 mg three times daily) to -2.19 log10 copies/mL at week 4 in the group receiving zidovudine plus HBY 097 (750 mg three times daily). After 12 weeks, these patients had viral RNA copy numbers 1.05 log10 below baseline. Genotypic analysis of resistance development revealed reverse transcriptase K103N variants in most patients, which was associated with less durable efficacy of HBY 097 treatment. Fewer patients receiving combination therapy with high-dose HBY 097 developed the K103N variant (P<.01). HBY 097 caused pronounced acute suppression of HIV-1 replication both in combination with zidovudine and alone. Therefore, sustained antiviral activity can be expected from multiple combination therapy regimens including a quinoxaline derivative.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-HIV Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antiviral Agents,
http://linkedlifedata.com/resource/pubmed/chemical/HBY 097,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Reverse Transcriptase,
http://linkedlifedata.com/resource/pubmed/chemical/Quinoxalines,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Reverse Transcriptase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Zidovudine
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0022-1899
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
179
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
709-13
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9952383-Adult,
pubmed-meshheading:9952383-Anti-HIV Agents,
pubmed-meshheading:9952383-Antiviral Agents,
pubmed-meshheading:9952383-CD4 Lymphocyte Count,
pubmed-meshheading:9952383-Dose-Response Relationship, Drug,
pubmed-meshheading:9952383-Double-Blind Method,
pubmed-meshheading:9952383-Drug Therapy, Combination,
pubmed-meshheading:9952383-Female,
pubmed-meshheading:9952383-HIV Infections,
pubmed-meshheading:9952383-HIV Reverse Transcriptase,
pubmed-meshheading:9952383-HIV-1,
pubmed-meshheading:9952383-Humans,
pubmed-meshheading:9952383-Male,
pubmed-meshheading:9952383-Quinoxalines,
pubmed-meshheading:9952383-RNA, Viral,
pubmed-meshheading:9952383-Reverse Transcriptase Inhibitors,
pubmed-meshheading:9952383-Time Factors,
pubmed-meshheading:9952383-Viral Load,
pubmed-meshheading:9952383-Zidovudine
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Antiviral activity of the human immunodeficiency virus type 1-specific nonnucleoside reverse transcriptase inhibitor HBY 097 alone and in combination with zidovudine in a phase II study. HBY 097/2001 Study Group.
|
| pubmed:affiliation |
Clinical Virology Unit, Glaxo Wellcome, Stevenage, Herts SG1 2NY, United Kingdom. jpk49970@GlaxoWellcome.co.uk
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study,
Clinical Trial, Phase II
|