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Predicate | Object |
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rdf:type | |
lifeskim:mentions |
umls-concept:C0010097,
umls-concept:C0011209,
umls-concept:C0031809,
umls-concept:C0040223,
umls-concept:C0086045,
umls-concept:C0162512,
umls-concept:C0220922,
umls-concept:C0349677,
umls-concept:C0392760,
umls-concept:C0439828,
umls-concept:C0456389,
umls-concept:C0520453,
umls-concept:C0574032,
umls-concept:C1521828
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pubmed:issue |
2
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pubmed:dateCreated |
1999-3-5
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pubmed:abstractText |
Although recent studies have shown that convection can be used to distribute macromolecules within the central nervous system (CNS) in a homogeneous, targeted fashion over clinically significant volumes and that the volume of infusion and target location (gray as opposed to white matter) influence distribution, little is known about other factors that may influence optimum use of convection-enhanced distribution. To understand the variables that affect convective delivery more fully, we examined the rate of infusion, delivery cannula size, concentration of infusate, and preinfusion sealing time.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-3085
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
315-20
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:9950503-Animals,
pubmed-meshheading:9950503-Catheterization,
pubmed-meshheading:9950503-Convection,
pubmed-meshheading:9950503-Corpus Striatum,
pubmed-meshheading:9950503-Drug Delivery Systems,
pubmed-meshheading:9950503-Equipment Design,
pubmed-meshheading:9950503-Female,
pubmed-meshheading:9950503-Osmolar Concentration,
pubmed-meshheading:9950503-Rats,
pubmed-meshheading:9950503-Rats, Sprague-Dawley,
pubmed-meshheading:9950503-Serum Albumin,
pubmed-meshheading:9950503-Time Factors
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pubmed:year |
1999
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pubmed:articleTitle |
Variables affecting convection-enhanced delivery to the striatum: a systematic examination of rate of infusion, cannula size, infusate concentration, and tissue-cannula sealing time.
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pubmed:affiliation |
Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1414, USA.
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pubmed:publicationType |
Journal Article
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