Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1999-4-13
|
| pubmed:abstractText |
A 29-y-old male attempted suicide with 3000 mg clozapine, 150 mg zopiclone, alprazolam and unknown quantities of alcohol. He was admitted in a deep hypotonic coma with respiratory depression, inhalation pneumonia and vascular collapse. Symptomatic treatment involved mechanical ventilation, vascular filling and antibiotics. The patient was discharged from the Intensive Care Unit 72 h after the suicide attempt with no sequelae. To detect and quantify clozapine in plasma, high-pressure liquid chromatography showed a 4 h absorption phase and a peak serum concentration of 5200 ng/ml. Three successive elimination t1/2 values of 38, 24 and 13 h were calculated.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0145-6296
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
41
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
20-2
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9949479-Adult,
pubmed-meshheading:9949479-Antipsychotic Agents,
pubmed-meshheading:9949479-Chromatography, High Pressure Liquid,
pubmed-meshheading:9949479-Clozapine,
pubmed-meshheading:9949479-Dose-Response Relationship, Drug,
pubmed-meshheading:9949479-Evaluation Studies as Topic,
pubmed-meshheading:9949479-Humans,
pubmed-meshheading:9949479-Male,
pubmed-meshheading:9949479-Schizophrenia,
pubmed-meshheading:9949479-Treatment Outcome
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Non-fatal clozapine (LEPONEX) intoxication with toxicokinetic evaluation.
|
| pubmed:affiliation |
Poison Centre, Pellegrin Hospital, Bordeaux, France.
|
| pubmed:publicationType |
Journal Article,
Case Reports
|