Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1977-1-25
pubmed:abstractText
Chicken embryo fibroblasts infected with an RNA- temperature-sensitive mutant (ts24) of Sindbis virus accumulated a large-molecular-weight protein (p200) when cells were shifted from the permissive to nonpermissive temperature. Appearance of p200 was accompanied by a decrease in the synthesis of viral structural proteins, but [35S]methionine tryptic peptides from p200 were different from those derived from a 140,000-molecular-weight polypeptide that contains the amino acid sequences of viral structural proteins. Among three other RNA- ts mutants that were tested for p200 formation, only one (ts21) produced this protein. The accumulation of p200 in ts24- and ts21-infected cells could be correlated with a shift in the formation of 42S and 26S viral RNA that led to an increase in the relative amounts of 42S RNA. These data indicate that p200 is translated from the nonstructural genes of the virion 42S RNA and further suggest that this RNA does not function effectively in vivo as an mRNA for the Sindbis virus structural proteins.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/994299-1182802, http://linkedlifedata.com/resource/pubmed/commentcorrection/994299-1264250, http://linkedlifedata.com/resource/pubmed/commentcorrection/994299-4374504, http://linkedlifedata.com/resource/pubmed/commentcorrection/994299-4416702, http://linkedlifedata.com/resource/pubmed/commentcorrection/994299-4515941, http://linkedlifedata.com/resource/pubmed/commentcorrection/994299-4525296, http://linkedlifedata.com/resource/pubmed/commentcorrection/994299-4673887, http://linkedlifedata.com/resource/pubmed/commentcorrection/994299-4688012, http://linkedlifedata.com/resource/pubmed/commentcorrection/994299-4734648, http://linkedlifedata.com/resource/pubmed/commentcorrection/994299-4736531, http://linkedlifedata.com/resource/pubmed/commentcorrection/994299-4798187, http://linkedlifedata.com/resource/pubmed/commentcorrection/994299-4818274, http://linkedlifedata.com/resource/pubmed/commentcorrection/994299-4851742, http://linkedlifedata.com/resource/pubmed/commentcorrection/994299-5058841, http://linkedlifedata.com/resource/pubmed/commentcorrection/994299-5461887, http://linkedlifedata.com/resource/pubmed/commentcorrection/994299-5723529, http://linkedlifedata.com/resource/pubmed/commentcorrection/994299-5761396, http://linkedlifedata.com/resource/pubmed/commentcorrection/994299-5817400, http://linkedlifedata.com/resource/pubmed/commentcorrection/994299-5919228, http://linkedlifedata.com/resource/pubmed/commentcorrection/994299-786155
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-538X
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
612-20
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
Formation of a Sindbis virus nonstructural protein and its relation of 42S mRNA function.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.