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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1977-1-25
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pubmed:abstractText |
The kinetics of bicarbonate-chloride exchange across the human red cell membrane was studied by following the time course of extracellular pH in a stopped-flow rapid-reaction apparatus during transfer of H+ into the cell by the CO2 hydration-dehydration cycle, under conditions where the rate of the process was determined by HCO3--Cl- exchange flux across the membrane. The flux of bicarbonate increased linearly with [HCO3-] gradient from 0.6 to 20 mM across the red cell membrane at both 37 degrees C and 2 degrees C, and decreased as transmembrane potential was increased by decreasing extracellular [Cl-]. An Arrhenius plot of the rate constants for the exchange indicates that the Q10 is strongly dependent on temperature, being about 1.7 between 24 degrees C and 42 degrees C and about 7 between 2 degrees C and 12 degrees C. These data agree well with the published values for Q10 of 1.2 between 24 degrees C and 40 degrees C and of 8 between 0 degrees C and 10 degrees C. The results suggest that different processes may determine the rate of HCO3--Cl- exchange at low vs. physiological temperatures, and that the functional (and/or structural) properties of the red cell membrane vary markedly with temperature.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/993774-13475180,
http://linkedlifedata.com/resource/pubmed/commentcorrection/993774-13910603,
http://linkedlifedata.com/resource/pubmed/commentcorrection/993774-14012797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/993774-14032069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/993774-14149678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/993774-14212152,
http://linkedlifedata.com/resource/pubmed/commentcorrection/993774-14257858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/993774-16748007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/993774-16994247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/993774-16994615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/993774-16994616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/993774-18099703,
http://linkedlifedata.com/resource/pubmed/commentcorrection/993774-237868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/993774-4365369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/993774-4433593,
http://linkedlifedata.com/resource/pubmed/commentcorrection/993774-4472868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/993774-4515993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/993774-4688320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/993774-4753421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/993774-4914412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/993774-4988892,
http://linkedlifedata.com/resource/pubmed/commentcorrection/993774-5071931,
http://linkedlifedata.com/resource/pubmed/commentcorrection/993774-5102608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/993774-5130630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/993774-5473503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/993774-5523740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/993774-5576765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/993774-5656372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/993774-5668450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/993774-6074969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/993774-6479
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-1295
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
633-52
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:993774-Bicarbonates,
pubmed-meshheading:993774-Biological Transport,
pubmed-meshheading:993774-Cell Membrane Permeability,
pubmed-meshheading:993774-Chlorides,
pubmed-meshheading:993774-Erythrocyte Membrane,
pubmed-meshheading:993774-Erythrocytes,
pubmed-meshheading:993774-Extracellular Space,
pubmed-meshheading:993774-Humans,
pubmed-meshheading:993774-Intracellular Fluid,
pubmed-meshheading:993774-Kinetics,
pubmed-meshheading:993774-Temperature
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pubmed:year |
1976
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pubmed:articleTitle |
Kinetics of bicarbonate-chloride exchange across the human red blood cell membrane.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
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