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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1999-2-25
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pubmed:abstractText |
We have evaluated Cu-diacetyl-bis(N4-methylthiosemicarbazone) (Cu-ATSM), an effective marker for the delineation of hypoxic but viable tissue, in vitro in the EMT6 carcinoma cell line under varying degrees of hypoxia and compared it with the flow tracer 64Cu-pyruvaldehyde-bis(N4-methylthiosemicarbazone) (Cu-PTSM) and the hypoxic tracer 18F-fluoromisonidazole (MISO). We have also compared the uptake of Cu-ATSM and Cu-PTSM in vivo and ex vivo in a murine animal model bearing the EMT6 tumor.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0161-5505
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
177-83
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:9935074-Animals,
pubmed-meshheading:9935074-Autoradiography,
pubmed-meshheading:9935074-Cell Hypoxia,
pubmed-meshheading:9935074-Drug Evaluation, Preclinical,
pubmed-meshheading:9935074-Female,
pubmed-meshheading:9935074-Mammary Neoplasms, Experimental,
pubmed-meshheading:9935074-Mice,
pubmed-meshheading:9935074-Mice, Inbred BALB C,
pubmed-meshheading:9935074-Misonidazole,
pubmed-meshheading:9935074-Organometallic Compounds,
pubmed-meshheading:9935074-Oxygen,
pubmed-meshheading:9935074-Thiosemicarbazones,
pubmed-meshheading:9935074-Tissue Distribution,
pubmed-meshheading:9935074-Tumor Cells, Cultured
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pubmed:year |
1999
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pubmed:articleTitle |
Evaluation of 64Cu-ATSM in vitro and in vivo in a hypoxic tumor model.
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pubmed:affiliation |
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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