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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
24
|
| pubmed:dateCreated |
1999-4-5
|
| pubmed:abstractText |
A novel class of CMV protease inhibitors based on a benzothiopyran-S,S-dioxide nucleus has been discovered. Enzyme kinetic data supports a reversible mode of inhibition for a representative member of this class, 2-(3-pyridyl-N-oxide)benzothiopyran-4-one-S,S-dioxide, 1. Experiments in the presence and absence of the disulfide reducing agent DTT suggest that the inhibition by 1 is not due to oxidative inactivation of the enzyme. Also presented are results of some SAR studies of the benzothiopyranone ring system.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
8
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3677-82
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9934494-Amino Acid Sequence,
pubmed-meshheading:9934494-Cytomegalovirus,
pubmed-meshheading:9934494-Molecular Sequence Data,
pubmed-meshheading:9934494-Oxidation-Reduction,
pubmed-meshheading:9934494-Pyrones,
pubmed-meshheading:9934494-Serine Endopeptidases,
pubmed-meshheading:9934494-Serine Proteinase Inhibitors,
pubmed-meshheading:9934494-Structure-Activity Relationship
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Benzothiopyran-4-one based reversible inhibitors of the human cytomegalovirus (HCMV) protease.
|
| pubmed:affiliation |
SmithKline Beecham Pharmaceuticals, Collegeville, PA 19426-0989, USA.
|
| pubmed:publicationType |
Journal Article
|