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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
24
|
| pubmed:dateCreated |
1999-4-5
|
| pubmed:abstractText |
A didemnin B analog containing a Tic (1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid) as a conformationally restrained replacement for tyrosine has been synthesized and shown to have comparable potency as a protein biosynthesis inhibitor. Synthetic highlights include an oxidation of an alcohol to an acid in the presence of the sensitive Tic heterocycle and a modified Schmidt-type one-pot macrocyclization.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
8
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3653-6
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:9934489-Animals,
pubmed-meshheading:9934489-Isoquinolines,
pubmed-meshheading:9934489-Molecular Structure,
pubmed-meshheading:9934489-Peptides, Cyclic,
pubmed-meshheading:9934489-Protein Synthesis Inhibitors,
pubmed-meshheading:9934489-Rabbits,
pubmed-meshheading:9934489-Structure-Activity Relationship,
pubmed-meshheading:9934489-Tetrahydroisoquinolines
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Synthesis and biological activity of [Tic5] didemnin B.
|
| pubmed:affiliation |
Department of Chemistry, University of Pennsylvania, Philadelphia 19104-6323, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|