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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
24
|
| pubmed:dateCreated |
1999-4-5
|
| pubmed:abstractText |
A set of HIV protease inhibitors represented by compound 2 has previously been described. Structural and conformational analysis of this compound suggested that conformational restriction of the P1/P2 portion of the molecule could lead to a novel set of potent protease inhibitors. Thus, probe compounds 3-7 were designed, synthesized, and found to be potent inhibitors of HIV protease.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0960-894X
|
| pubmed:author |
pubmed-author:BakerC TCT,
pubmed-author:CourtJ JJJ,
pubmed-author:DeiningerD DDD,
pubmed-author:KimE EEE,
pubmed-author:MICC,
pubmed-author:NovakP MPM,
pubmed-author:PazhanisamySS,
pubmed-author:PorterM DMD,
pubmed-author:RayB ABA,
pubmed-author:SalituroF GFG,
pubmed-author:SchairerW CWC,
pubmed-author:TungR DRD
|
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
8
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
3637-42
|
| pubmed:dateRevised |
2001-11-13
|
| pubmed:meshHeading | |
| pubmed:year |
1998
|
| pubmed:articleTitle |
Design and synthesis of novel conformationally restricted HIV protease inhibitors.
|
| pubmed:affiliation |
Vertex Pharmaceuticals Incorporated, Cambridge, MA 02139, USA.
|
| pubmed:publicationType |
Journal Article
|