rdf:type |
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lifeskim:mentions |
|
pubmed:issue |
24
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pubmed:dateCreated |
1999-4-5
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pubmed:abstractText |
Four 7-[3-(4-phenyl-1-piperazinyl)propoxy]coumarins were synthesized. The affinities of these compounds for DA (D2A, D3) and 5HT1A receptors were evaluated for their ability to displace [3H]-raclopride and [3H]-8-OH-DPAT respectively from their specific binding sites. The affinities of the target compounds were all in the nanomolar range and followed the order 5-HT1A > D2 > D3.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DRD3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Drd3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D3,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin, 5-HT1,
http://linkedlifedata.com/resource/pubmed/chemical/phenylpiperazine
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0960-894X
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:day |
15
|
pubmed:volume |
8
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
3567-70
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:9934472-Animals,
pubmed-meshheading:9934472-CHO Cells,
pubmed-meshheading:9934472-Cricetinae,
pubmed-meshheading:9934472-Humans,
pubmed-meshheading:9934472-Mice,
pubmed-meshheading:9934472-Piperazines,
pubmed-meshheading:9934472-Radioligand Assay,
pubmed-meshheading:9934472-Receptors, Dopamine D2,
pubmed-meshheading:9934472-Receptors, Dopamine D3,
pubmed-meshheading:9934472-Receptors, Serotonin,
pubmed-meshheading:9934472-Receptors, Serotonin, 5-HT1
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pubmed:year |
1998
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pubmed:articleTitle |
Phenylpiperazine derivatives with strong affinity for 5HT1A, D2A and D3 receptors.
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pubmed:affiliation |
Department of Physical Chemistry and Organic Chemistry, University of Vigo, Spain.
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pubmed:publicationType |
Journal Article
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