Linked Life Data

9934452

Source:http://linkedlifedata.com/resource/pubmed/id/9934452

Statements in which the resource exists.
SubjectPredicateObjectContext
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pubmed-article:9934452pubmed:abstractTextAromatic analogs of arcaine were shown to have inhibitory effects on the binding of the channel blocking drug [3H]MK-801 to the NMDA receptor complex. The most potent compound of the series was an N,N'-bis(propyl)guanidinium which inhibited [3H]MK-801 binding with an IC50 of 0.58 microM and an IC50 of 12.17 microM upon addition of 100 microM spermidine. The increase in IC50 upon addition of spermidine suggests competitive antagonism between the inhibitor and spermidine at the arcaine-sensitive polyamine site of the NMDA receptor complex.lld:pubmed
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pubmed-article:9934452pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:9934452pubmed:articleTitleAromatic analogs of arcaine inhibit MK-801 binding to the NMDA receptor.lld:pubmed
pubmed-article:9934452pubmed:affiliationDepartment of Pharmacology, University of Pittsburgh, PA 15260, USA.lld:pubmed
pubmed-article:9934452pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:9934452pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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