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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1999-4-14
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pubmed:abstractText |
Experimental brain tumor gene therapy with the herpes simplex virus thymidine kinase (HSV-tk) gene has demonstrated that not only HSV-tk transduced but surrounding non-HSV-tk transduced cells are killed when given ganciclovir. This so-called bystander effect has recently been shown to be dependent on connexin-mediated intercellular communication. To assess potential susceptibility to the bystander effect, we examined levels of connexin-26 and connexin-43 expression in a series of primary brain tumors. Connexin-26 expression has not previously been studied in primary brain tumors and connexin-43 expression has not been studied in nonastrocytic primary brain tumors. We also attempted to enhance the bystander effect in vitro by overexpressing connexin in tumor cells with high basal levels of connexin expression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0148-396X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
361-8; discussion 368-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9932890-Animals,
pubmed-meshheading:9932890-Blotting, Western,
pubmed-meshheading:9932890-Brain,
pubmed-meshheading:9932890-Brain Neoplasms,
pubmed-meshheading:9932890-Cell Count,
pubmed-meshheading:9932890-Connexin 43,
pubmed-meshheading:9932890-Connexins,
pubmed-meshheading:9932890-Epilepsy,
pubmed-meshheading:9932890-Ganciclovir,
pubmed-meshheading:9932890-Gene Expression,
pubmed-meshheading:9932890-Gene Therapy,
pubmed-meshheading:9932890-Humans,
pubmed-meshheading:9932890-Immunohistochemistry,
pubmed-meshheading:9932890-Rats,
pubmed-meshheading:9932890-Simplexvirus,
pubmed-meshheading:9932890-Thymidine Kinase,
pubmed-meshheading:9932890-Transfection,
pubmed-meshheading:9932890-Tumor Cells, Cultured
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pubmed:year |
1999
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pubmed:articleTitle |
Connexins are expressed in primary brain tumors and enhance the bystander effect in gene therapy.
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pubmed:affiliation |
Department of Neurosurgery, New England Medical Center, Boston, Massachusetts 02111, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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