| pubmed-article:9932608 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9932608 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:9932608 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:9932608 | lifeskim:mentions | umls-concept:C0025932 | lld:lifeskim |
| pubmed-article:9932608 | lifeskim:mentions | umls-concept:C0016055 | lld:lifeskim |
| pubmed-article:9932608 | lifeskim:mentions | umls-concept:C0024623 | lld:lifeskim |
| pubmed-article:9932608 | lifeskim:mentions | umls-concept:C0001511 | lld:lifeskim |
| pubmed-article:9932608 | lifeskim:mentions | umls-concept:C0007595 | lld:lifeskim |
| pubmed-article:9932608 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
| pubmed-article:9932608 | lifeskim:mentions | umls-concept:C0055023 | lld:lifeskim |
| pubmed-article:9932608 | lifeskim:mentions | umls-concept:C1514559 | lld:lifeskim |
| pubmed-article:9932608 | lifeskim:mentions | umls-concept:C0041243 | lld:lifeskim |
| pubmed-article:9932608 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:9932608 | lifeskim:mentions | umls-concept:C1519697 | lld:lifeskim |
| pubmed-article:9932608 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:9932608 | pubmed:dateCreated | 1999-2-25 | lld:pubmed |
| pubmed-article:9932608 | pubmed:abstractText | It has previously been reported that the trypsinogen gene is expressed in various human cancers. To investigate the possible role of trypsin in tumor malignancy, trypsinogen-1 cDNA was introduced into the human gastric carcinoma cell line MKN-1. The overexpression of trypsinogen-1 in MKN-1 cells stimulated cellular growth and adhesion to fibronectin and vitronectin when the trypsinogen activator enterokinase was added into the culture. Enterokinase treatment of the conditioned medium of the MKN-1 transfectants partially converted the proforms of gelatinases B and A to their apparent active forms. When the MKN-1 transfectants expressing trypsinogen-1 were intraperitoneally transplanted into nude mice, the mice frequently produced tumors in the colon, spleen and liver. However, the mice implanted with control MKN-1 cells produced no tumors. These results strongly suggest that tumor-derived trypsin contributes to the disseminated growth of some types of cancer cells including gastric cancer. | lld:pubmed |
| pubmed-article:9932608 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9932608 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9932608 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9932608 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:9932608 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9932608 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9932608 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:9932608 | pubmed:issn | 0262-0898 | lld:pubmed |
| pubmed-article:9932608 | pubmed:author | pubmed-author:KatoYY | lld:pubmed |
| pubmed-article:9932608 | pubmed:author | pubmed-author:MiyataSS | lld:pubmed |
| pubmed-article:9932608 | pubmed:author | pubmed-author:MiyazakiKK | lld:pubmed |
| pubmed-article:9932608 | pubmed:author | pubmed-author:NagashimaYY | lld:pubmed |
| pubmed-article:9932608 | pubmed:author | pubmed-author:MisugiKK | lld:pubmed |
| pubmed-article:9932608 | pubmed:author | pubmed-author:MiyagiYY | lld:pubmed |
| pubmed-article:9932608 | pubmed:author | pubmed-author:KoshikawaNN | lld:pubmed |
| pubmed-article:9932608 | pubmed:author | pubmed-author:YasumitsuHH | lld:pubmed |
| pubmed-article:9932608 | pubmed:author | pubmed-author:HiraharaFF | lld:pubmed |
| pubmed-article:9932608 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9932608 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:9932608 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9932608 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9932608 | pubmed:pagination | 613-22 | lld:pubmed |
| pubmed-article:9932608 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:9932608 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9932608 | pubmed:articleTitle | Stimulation of cellular growth and adhesion to fibronectin and vitronectin in culture and tumorigenicity in nude mice by overexpression of trypsinogen in human gastric cancer cells. | lld:pubmed |
| pubmed-article:9932608 | pubmed:affiliation | Kihara Institute for Biological Research, and Graduate School of Integrated Science, Yokohama City University, Yokohama, Japan. | lld:pubmed |
| pubmed-article:9932608 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9932608 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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