Linked Life Data

9932017

Source:http://linkedlifedata.com/resource/pubmed/id/9932017

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1999-3-15
pubmed:abstractText
This report summarises some features of the gastric enteric nervous system in the guinea-pig model. Particular attention has been paid to relations between neurochemical properties, electrophysiological and putative function of enteric neurones. (1) Cholinergic and nitrergic neurones form separate neuronal populations. (2) Ascending neurones outnumbered descending ones. (3) Transmitter-phenotype and projection were related: cholinergic neurones were primarily ascending while nitrergic neurones were mainly descending. (4) The neurochemical code, i.e. the transmitter colocalisation, could be related to the function of enteric neurones. Colocalisation of substance P and/or enkephaline in cholinergic neurones was characteristic for ascending excitatory muscle neurones. Descending inhibitory muscle neurones were nitrergic often colocalising the neuropeptides neuropeptide Y (NPY) and vasoactive intestinal peptide (VIP). In the intrinsic innervation of the gastric mucosa NPY/VIP was abundant and colocalised in ascending cholinergic as well as descending nitrergic neurones. (5) The vast majority of ascending and descending interneurones were cholinergic and often colocalised NPY. (6) The majority of descending mucosa and descending inhibitory muscle neurones were tonically-firing neurones. Our results revealed the characteristics of some neural components within the enteric nervous system of the stomach which are involved in modulation of mucosa and muscle functions. It may be concluded that muscle and mucosa functions are under the control of the enteric nervous system which contains distinct populations responsible for motor and secretory activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0341-6593
pubmed:author
pubmed:issnType
Print
pubmed:volume
105
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
461-5
pubmed:dateRevised
2007-7-24
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Structural and functional organization of the enteric nervous system in the stomach.
pubmed:affiliation
School of Veterinary Medicine, Department of Physiology, Hannover, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't