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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1 Pt 2
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pubmed:dateCreated |
1999-2-26
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pubmed:abstractText |
Pressure overload ventricular hypertrophy is accompanied by dysfunctional beta-adrenergic receptor signaling due to increased levels of the beta-adrenergic receptor kinase-1, which phosphorylates and desensitizes beta-adrenergic receptors. In this study, we examined whether increased beta-adrenergic receptor kinase 1 expression is associated with myocardial hypertrophy induced by adrenergic stimulation. With use of implanted mini-osmotic pumps, we treated mice with isoproterenol, phenylephrine, or vehicle to distinguish between alpha1- and beta-adrenergic stimulation. Both treatments resulted in cardiac hypertrophy, but only isoproterenol induced significant increases in beta-adrenergic receptor kinase-1 protein levels and activity. Similarly, in isolated adult rat cardiac myocytes, 24 hours of isoproterenol stimulation resulted in a significant 2.8-fold increase in beta-adrenergic receptor kinase-1 protein levels, whereas 24 hours of phenylephrine treatment did not alter beta-adrenergic receptor kinase-1 expression. Our results indicate that increased beta-adrenergic receptor kinase-1 is not invariably associated with myocardial hypertrophy but apparently is controlled by the state of beta-adrenergic receptor activation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenylate Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic alpha-Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP-Dependent Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Isoproterenol,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, alpha-1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta,
http://linkedlifedata.com/resource/pubmed/chemical/beta-Adrenergic Receptor Kinases
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0194-911X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
396-401
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9931136-Adenylate Cyclase,
pubmed-meshheading:9931136-Adrenergic alpha-Agonists,
pubmed-meshheading:9931136-Adrenergic beta-Agonists,
pubmed-meshheading:9931136-Animals,
pubmed-meshheading:9931136-Body Weight,
pubmed-meshheading:9931136-Cardiomegaly,
pubmed-meshheading:9931136-Cells, Cultured,
pubmed-meshheading:9931136-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:9931136-GTP-Binding Proteins,
pubmed-meshheading:9931136-Heart,
pubmed-meshheading:9931136-Heart Ventricles,
pubmed-meshheading:9931136-Infusion Pumps,
pubmed-meshheading:9931136-Isoproterenol,
pubmed-meshheading:9931136-Mice,
pubmed-meshheading:9931136-Mice, Inbred C57BL,
pubmed-meshheading:9931136-Myocardium,
pubmed-meshheading:9931136-Organ Size,
pubmed-meshheading:9931136-Phenylephrine,
pubmed-meshheading:9931136-Radioligand Assay,
pubmed-meshheading:9931136-Rats,
pubmed-meshheading:9931136-Rats, Sprague-Dawley,
pubmed-meshheading:9931136-Receptors, Adrenergic, alpha-1,
pubmed-meshheading:9931136-Receptors, Adrenergic, beta,
pubmed-meshheading:9931136-Signal Transduction,
pubmed-meshheading:9931136-beta-Adrenergic Receptor Kinases
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pubmed:year |
1999
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pubmed:articleTitle |
Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation.
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pubmed:affiliation |
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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