Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1977-1-28
pubmed:abstractText
Chlorpromazine (CPZ) and three other phenothiazines and the structurally related antidepressant drugs imipramine and amitriptyline were found to depress human neutrophil chemotactic responsiveness. A 7 X 10(-6)M solution of CPZ inhibited chemotaxis, whereas concentrations of the other tested drugs 10 to 1,000 times greater than this were needed to inhibit chemotaxis. This effect of CPZ could not, however, be demonstrated when testing neutrophils from patients treated with the drug. The inhibition of chemotaxis was reversible when CPZ-incubated neutrophils were washed before testing for chemotactic responsiveness. CPZ affects neutrophil funcjtion as well as other aspects of immune response.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/992875-1244420, http://linkedlifedata.com/resource/pubmed/commentcorrection/992875-13365522, http://linkedlifedata.com/resource/pubmed/commentcorrection/992875-13394752, http://linkedlifedata.com/resource/pubmed/commentcorrection/992875-14205646, http://linkedlifedata.com/resource/pubmed/commentcorrection/992875-165364, http://linkedlifedata.com/resource/pubmed/commentcorrection/992875-4565956, http://linkedlifedata.com/resource/pubmed/commentcorrection/992875-5020659, http://linkedlifedata.com/resource/pubmed/commentcorrection/992875-5020660, http://linkedlifedata.com/resource/pubmed/commentcorrection/992875-5020661, http://linkedlifedata.com/resource/pubmed/commentcorrection/992875-5410895, http://linkedlifedata.com/resource/pubmed/commentcorrection/992875-5696876
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
948-50
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
Inhibition of human neutrophil chemotaxis in vitro by phenothiazines and related compounds.
pubmed:publicationType
Journal Article