Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1977-1-28
pubmed:abstractText
Using a semimicromethod with washed whole blood, in vitro lymphocyte responses of rabbits to intradermal infection with vaccinia virus was studied. Peritoneal exudate macrophages were infected with vaccinia in vitro to determine the time of appearance of activated macrophages. After primary infection, an increase in spontaneous incorporation of thymidine by blood cultures was found as early as 2 days postinfection. This effect was at a maximum at 7 to 10 days, with counts up to 100-fold higher than before infection. Incubation of these cultures with concanavalin A showed a marked decrease in stimulation index as compared with normals. Although only a transient stimulation with vaccinia was found during the acute infection, stimulation indexes of 2 to 3 were obtained during convalescence. Macrophages from rabbits early after infection supported vaccinia replication, whereas those at day 6 or later resisted infection. Macrophage resistance persisted for 2 to 3 weeks. The response of lymphocytes from rabbits reinfected with vaccinia after 15 weeks differed, with a small increase in spontaneous thymidine uptake, a smaller depression in concanavalin A stimulation, and a greater specific response to vaccinia. Macrophage activation occurred earlier and persisted for a longer time after secondary infection.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/992867-1090672, http://linkedlifedata.com/resource/pubmed/commentcorrection/992867-1151122, http://linkedlifedata.com/resource/pubmed/commentcorrection/992867-16557917, http://linkedlifedata.com/resource/pubmed/commentcorrection/992867-4102688, http://linkedlifedata.com/resource/pubmed/commentcorrection/992867-4137839, http://linkedlifedata.com/resource/pubmed/commentcorrection/992867-4335071, http://linkedlifedata.com/resource/pubmed/commentcorrection/992867-4358302, http://linkedlifedata.com/resource/pubmed/commentcorrection/992867-4359780, http://linkedlifedata.com/resource/pubmed/commentcorrection/992867-4372170, http://linkedlifedata.com/resource/pubmed/commentcorrection/992867-4543313, http://linkedlifedata.com/resource/pubmed/commentcorrection/992867-4630775, http://linkedlifedata.com/resource/pubmed/commentcorrection/992867-46908, http://linkedlifedata.com/resource/pubmed/commentcorrection/992867-4948685, http://linkedlifedata.com/resource/pubmed/commentcorrection/992867-4986255, http://linkedlifedata.com/resource/pubmed/commentcorrection/992867-5005299, http://linkedlifedata.com/resource/pubmed/commentcorrection/992867-5489068, http://linkedlifedata.com/resource/pubmed/commentcorrection/992867-5549896, http://linkedlifedata.com/resource/pubmed/commentcorrection/992867-5576335, http://linkedlifedata.com/resource/pubmed/commentcorrection/992867-806355, http://linkedlifedata.com/resource/pubmed/commentcorrection/992867-811559
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1014-21
pubmed:dateRevised
2010-9-3
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
Lymphocyte and macrophage responses after vaccinia virus infections.
pubmed:publicationType
Journal Article