Linked Life Data

9928206

Source:http://linkedlifedata.com/resource/pubmed/id/9928206

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1999-2-16
pubmed:abstractText
Infection in transplantation results from interaction between the level of immune suppression and the epidemiologic exposures of the recipient. "Xenosis," infection in xenotransplantation, may be increased beyond that of allotransplantation because: (1) the xenograft may serve as a permissive focus of infection for donor-derived organisms; (2) these organisms may be unknown or xenotropic; (3) microbiologic assays may be unavailable; (4) clinical syndromes due to such novel pathogens may not be recognized; (5) the necessary level of immune suppression may be greater than for allotransplantation; (6) donor-derived organisms may acquire new (e.g., genetic) characteristics in the human host; (7) the presence of immune suppression and the high, intrinsic rate of infection may mask the presence of xenosis; and (8) MHC-incompatibility may reduce the efficacy of the immune response within the xenograft. Because immunocompromised individuals are sentinels for infection by many types of novel infectious agents, and because there is some unknown level of risk that such pathogens will spread to the general population, microbiologic studies must be initiated in tandem with preclinical and clinical studies of xenotransplantation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0077-8923
pubmed:author
pubmed:issnType
Print
pubmed:day
30
pubmed:volume
862
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
52-66
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Infection and xenotransplantation. Developing strategies to minimize risk.
pubmed:affiliation
Infectious Disease Unit, Massachusetts General Hospital, Boston, USA. jfishman@helix.mgh.harvard.edu
pubmed:publicationType
Journal Article, Review