Linked Life Data

9928158

Source:http://linkedlifedata.com/resource/pubmed/id/9928158

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1999-2-16
pubmed:abstractText
Studies on the regulation of galanin expression in the epithelial cells of the anterior pituitary gland have provided a wealth of insight into the cellular and molecular biology of this unique peptide. Galanin is localized within subpopulations of specific pituitary cell types, and hypothalamic as well as gonadal factors including dopamine, somatostatin, thyrotropin-releasing hormone, growth hormone-releasing hormone (GHRH), estrogen, and progesterone dynamically regulate its expression and release. Galanin gene expression and peptide secretion are markedly increased in estrogen-induced prolactinomas, wherein galanin serves as both an autocrine and paracrine hormone regulating prolactin secretion. Galanin mRNA and peptide levels are also dramatically elevated in somatotroph adenomas of human GHRH transgenic mice. Moreover, galanin secretion is increased from the hyperplastic somatotrophs of hGHRH transgenic mice. However, not all pituitary adenomas are associated with increased galanin gene expression; galanin synthesis is repressed in 131I-induced thyrotroph adenomas. Thus, galanin acts locally to regulate pituitary hormone secretion and appears to act as a mitogenic factor to increase the proliferation of pituitary cells in a cell-type specific manner.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0077-8923
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
863
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
48-55
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Galanin in normal and hyperplastic anterior pituitary cells. From pituitary tumor cell lines to transgenic mice.
pubmed:affiliation
Department of Anatomy and Neurobiology, University of Kentucky Medical Center, Lexington 40536, USA. jfhyde00@pop.uky.edu
pubmed:publicationType
Journal Article, Review